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Idiopathic membranous nephropathy

LY75 · rs4664308

Where this position leads

Condition: Idiopathic Membranous Nephropathy

rs4664308 Condition: Idiopathic Membranous Nephropathy Idiopathic Membranous Nephropathy Condition rs4664308 rs4664308 LY75

What the study found

Who was studied 556 European ancestry cases, 2,338 European ancestry controls.

The effect Each copy of the A allele carried 2.28 times the odds of Idiopathic membranous nephropathy (95% confidence interval 1.96-2.64); p = 9 × 10−29.

How common The A allele had a frequency of about 43% in the people studied.

Where it sits Chromosome 2, band 2q24.2 — in an intron of PLA2R1.

What each result means

A/A Two copies of the version the research linked to Idiopathic membranous nephropathy. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Idiopathic membranous nephropathy. That is a smaller link than two copies.
G/G No copy of the version the research linked to Idiopathic membranous nephropathy. This is the starting point the study compared everyone against.
Source

What people read about alongside this

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs4664308

What is rs4664308?

rs4664308 is a single position in the genome, in or near the LY75 gene. Published research associates it with idiopathic membranous nephropathy. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4664308 linked to?

On MyGeneLog this position is linked to Idiopathic Membranous Nephropathy. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs4664308?

Subjects that appear in the title or abstract of the same papers as this rsID include infection and immunity (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs4664308 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4664308 come from?

GWAS Catalog, N Engl J Med 2011, PMID:21323541. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Idiopathic membranous nephropathy (rs4664308). MyGeneLog™. https://www.mygenelog.com/variants/rs4664308

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