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Hepatitis B

HLA-DPA1 · rs3077

Where this position leads

Condition: Chronic Hepatitis B

rs3077 Condition: Chronic Hepatitis B Chronic Hepatitis B Condition Topic: Infection and immunity Infection and immunity Topic Topic: Liver Liver Topic rs3077 rs3077 HLA-DPA1

Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.

What the study found

Who was studied 458 Japanese ancestry cases, 2,056 Japanese ancestry controls; replicated in 2,209 Japanese ancestry cases, 4,440 Japanese ancestry controls.

The effect Each copy of the G allele carried 1.87 times the odds of Hepatitis B (95% confidence interval 1.73-2.01); p = 2 × 10−61.

How common The G allele had a frequency of about 60% in the people studied.

Where it sits Chromosome 6, band 6p21.32 — in the 3′ untranslated region of HLA-DPA1.

What each result means

A/A No copy of the version the research linked to Hepatitis B. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Hepatitis B. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Hepatitis B. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population
Mbarek H, Ochi H, Urabe Y, Kumar V, Kubo M, Hosono N, Takahashi A, Kamatani Y, Miki D, Abe H, Tsunoda T, Kamatani N
and 3 more — show all
Chayama K, Nakamura Y, Matsuda K
Human molecular genetics · 2011 · PMID 21750111

What people read about alongside this

Infection and immunity60 Liver15 Alcohol and the flush1 Blood sugar and insulin1 Natural selection1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs3077

What is rs3077?

rs3077 is a single position in the genome, in or near the HLA-DPA1 gene. Published research associates it with hepatitis b. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs3077 linked to?

On MyGeneLog this position is linked to Chronic Hepatitis B. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs3077?

Subjects that appear in the title or abstract of the same papers as this rsID include infection and immunity (60 papers), liver (15 papers), alcohol and the flush (1 papers), blood sugar and insulin (1 papers), natural selection (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs3077 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3077 come from?

GWAS Catalog, Hum Mol Genet 2011, PMID:21750111. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Hepatitis B (rs3077). MyGeneLog™. https://www.mygenelog.com/variants/rs3077

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