Why this topic Strength training went mainstream at the same time as running.
From our blog
What this topic connects to
Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
Variants that share a paper with this
Counted in Europe PMC, where the title or abstract names both this topic and that rsID. The number is papers, not evidence of a cause.
rs9939609
FTO
Menarche (age at onset)
97 papers →rs1815739
ACTN3
Muscle fiber type ("sprinter gene")
36 papers →rs6265
BDNF
Smoking behavior
27 papers →rs1421085
FTO
Obesity
15 papers →rs8050136
FTO
Type 2 diabetes
10 papers →rs429358
APOE
Lewy body disease
9 papers →rs12970134
MC4R
Waist circumference and related phenotypes
7 papers →rs1801133
MTHFR
Folate metabolism (MTHFR C677T)
7 papers →rs671
ALDH2
Alcohol flush reaction
7 papers →rs1799945
HFE
Iron overload risk (HFE H63D)
5 papers →rs1799964
HLA-DQA2
Crohn's disease
5 papers →rs2282679
GC
Vitamin D levels
5 papers →rs1799971
OPRM1
Opioid receptor sensitivity
4 papers →rs662799
APOA5
Triglyceride levels
4 papers →rs9930506
FTO
Obesity-related traits
4 papers →rs1532624
NLRC5
HDL cholesterol
3 papers →rs1805096
LEPR
C-reactive protein
3 papers →rs4343
ACE
Angiotensin-converting enzyme activity
3 papers →rs4988235
MCM6 / LCT
Lactose tolerance
3 papers →rs780094
GCKR
Uric acid levels
3 papers →rs10938397
GNPDA2
Obesity
2 papers →rs1229984
ADH1B
Alcohol metabolism speed
2 papers →rs2014355
ACADS
Metabolite levels
2 papers →rs2216405
CPS1
Metabolic traits
2 papers →rs2286963
ACADL
Metabolite levels
2 papers →rs2954029
TRIB1
Triglycerides
2 papers →rs340874
PROX1
Psoriasis or type 2 diabetes (trans-disease meta-analysis)(opposite effect)
2 papers →rs3736228
LRP5
Bone mineral density
2 papers →rs3764261
CETP
HDL cholesterol
2 papers →rs3798220
LPA
Coronary heart disease
2 papers →rs5370
EDN1
Circulating vasoactive peptide levels
2 papers →rs603424
SCD
Metabolic traits
2 papers →rs6499640
FTO
Body mass index
2 papers →rs6567160
near MC4R
Childhood obesity
2 papers →rs7094971
SLC16A9
Metabolic traits
2 papers →rs7832552
TRHR
Body mass (lean)
2 papers →rs8396
ETFDH
Metabolite levels
2 papers →rs9393903
ELOVL2
Metabolic traits
2 papers →rs10146997
NRXN3
Waist circumference
1 paper →rs10246939
TAS2R38
Bitter taste perception (TAS2R38 position 296)
1 paper →rs10455872
LPA
Parental lifespan (LPA, lipoprotein(a))
1 paper →rs1051730
CHRNA3
Smoking behavior
1 paper →rs10906115
CDC123
Type 2 diabetes
1 paper →rs10941679
near MRPS30
Breast cancer
1 paper →rs11030104
BDNF
Body mass index
1 paper →rs11558471
SLC30A8
Proinsulin levels
1 paper →rs11671664
GIPR
Body mass index (SNP x SNP interaction)
1 paper →rs11676272
ADCY3
Body mass index
1 paper →rs12150660
SHBG
Testosterone levels
1 paper →rs1470579
IGF2BP2
Type 2 diabetes
1 paper →rs1481012
ABCG2
Gout
1 paper →rs1558902
FTO
Obesity
1 paper →rs17249754
ATP2B1
Blood pressure
1 paper →rs174583
FADS2
QT interval
1 paper →rs1799884
GCK
Glycated hemoglobin levels
1 paper →rs1799969
ICAM1
Soluble ICAM-1
1 paper →rs1800469
TGFB1
Colorectal cancer
1 paper →rs1801131
MTHFR
Folate metabolism (MTHFR A1298C)
1 paper →rs182052
ADIPOQ
Adiponectin levels
1 paper →rs1883025
ABCA1
HDL cholesterol
1 paper →rs2000999
HPR
LDL cholesterol
1 paper →rs2046210
ESR1
Breast cancer
1 paper →rs2070600
AGER
Pulmonary function
1 paper →rs2097677
IL6
C-reactive protein
1 paper →rs267939
DAP
Ulcerative colitis
1 paper →rs2736098
ZDHHC11
Pancreatic cancer
1 paper →rs2736100
TERT
Lung adenocarcinoma
1 paper →rs3101336
NEGR1
Obesity
1 paper →rs326
SLC18A1
Triglycerides
1 paper →rs3757318
ESR1
Breast cancer
1 paper →rs3794060
DHCR7
Systemic lupus erythematosus
1 paper →rs3817198
LSP1
Breast cancer
1 paper →rs401681
TERT
Serum prostate-specific antigen levels
1 paper →rs459193
ANKRD55
Waist-to-hip ratio adjusted for body mass index
1 paper →rs4804416
INSR
Thyroid hormone levels
1 paper →rs4870044
ESR1
Bone mineral density (spine)
1 paper →rs5215
KCNJ11
Type 2 diabetes
1 paper →rs5498
ICAM1
Soluble ICAM-1
1 paper →rs55743914
PTPRK
Celiac disease
1 paper →rs560887
G6PC2
Fasting plasma glucose
1 paper →rs5742692
IGF1
Height
1 paper →rs574367
SEC16B
Body mass index
1 paper →rs6025
F5
Blood clotting risk (Factor V Leiden)
1 paper →rs6235
PCSK1
Proinsulin levels
1 paper →rs6687758
DUSP10
Colorectal cancer
1 paper →rs693
APOB
Cholesterol, total
1 paper →rs6983267
POU5F1B
Prostate cancer
1 paper →rs713598
TAS2R38
Bitter taste perception (PTC/PROP tasting)
1 paper →rs7524102
ZBTB40
Bone mineral density (spine)
1 paper →rs762551
CYP1A2
Caffeine metabolism
1 paper →rs7647305
SFRS10
Body mass index
1 paper →rs780093
GCKR
Crohn's disease
1 paper →rs7901695
TCF7L2
Type 2 diabetes
1 paper →rs8099917
IL29
Chronic hepatitis C infection
1 paper →rs9364554
SLC22A3
Prostate cancer
1 paper →rs9389269
HBS1L
Red blood cell traits
1 paper →rs964184
ZNF259
Triglyceride levels
1 paper →rs987237
TFAP2B
Adiposity
1 paper →How this was counted
Europe PMC, title and abstract only, searched for “muscle fiber type”, “physical activity”, “athletic performance”, “exercise capacity” alongside each published rsID. Full text was not counted: it returns every paper with an rsID buried in a supplementary table. Recounted monthly.
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Exercise and muscle. MyGeneLog™. https://www.mygenelog.com/topics/exercise
Questions about Exercise and muscle
What is Exercise and muscle?
Exercise and muscle is this site's topic page for muscle-performance genetics — including the "sprinter gene," the single most oversold result in consumer genetics.
Is the "sprinter gene" real?
It is real as a variant, but the claims made about it are the most oversold result in consumer genetics. A single gene does not make an athlete, and this topic exists partly to say so plainly.
Why is exercise and muscle a topic on this site now?
Strength training went mainstream at the same time running did, and both trends now come with genetic claims attached that deserve the same scrutiny.
How does this site decide which variants are linked to exercise and muscle?
Europe PMC is searched for muscle fiber type, physical activity, athletic performance or exercise capacity appearing in a paper's title or abstract alongside a published rsID, recounted every month.