Sensitive

Type 2 diabetes

CDC123 · rs10906115

Where this position leads

Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.

What the study found

Who was studied 1,019 Chinese ancestry cases, 1,710 Chinese ancestry controls; replicated in 2,591 European ancestry cases, 3,052 European ancestry controls, 6,184 East Asian cases, 9,853 East Asian controls.

The effect Each copy of the A allele carried 1.13 times the odds of Type 2 diabetes (95% confidence interval 1.08-1.18); p = 1 × 10⁻⁸.

How common The A allele had a frequency of about 57% in the people studied.

Where it sits Chromosome 10, band 10p13 — between genes, 22.4 kb from CDC123.

What each result means

A/A Two copies of the version the research linked to Type 2 diabetes. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Type 2 diabetes. That is a smaller link than two copies.

G/G No copy of the version the research linked to Type 2 diabetes. This is the starting point the study compared everyone against.

Source

Identification of new genetic risk variants for type 2 diabetes

Shu XO, Long J, Cai Q, Qi L, Xiang YB, Cho YS, Tai ES, Li X, Lin X, Chow WH, Go MJ, Seielstad M

and 19 more — show all

Bao W, Li H, Cornelis MC, Yu K, Wen W, Shi J, Han BG, Sim XL, Liu L, Qi Q, Kim HL, Ng DP, Lee JY, Kim YJ, Li C, Gao YT, Zheng W, Zheng W, Hu FB

PLoS genetics · 2010 · PMID 20862305 · open access

What people read about alongside this

Blood sugar and insulin4 Exercise and muscle1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs10906115

What is rs10906115?

rs10906115 is a single position in the genome, in or near the CDC123 gene. Published research associates it with type 2 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10906115 linked to?

On MyGeneLog this position is linked to Type 2 Diabetes. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs10906115?

Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (4 papers), exercise and muscle (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs10906115 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10906115 come from?

GWAS Catalog, PLoS Genet 2010, PMID:20862305. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Type 2 diabetes (rs10906115). MyGeneLog™. https://www.mygenelog.com/variants/rs10906115

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