Standard

Waist circumference

NRXN3 · rs10146997

Where this position leads

Condition: Waist Circumference

rs10146997 Condition: Waist Circumference Waist Circumference Condition Topic: Blood sugar and insulin Blood sugar and insulin Topic rs10146997 rs10146997 NRXN3

Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.

What the study found

Who was studied 31,373 European ancestry individuals; replicated in 38,641 individuals.

The effect Each copy of the G allele shifted the measure 0.65 cm higher; p = 5 × 10−8.

Where it sits Chromosome 14, band 14q31.1 — in an intron of NRXN3.

What each result means

A/A No copy of the version the research linked to Waist circumference. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Waist circumference. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Waist circumference. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

What people read about alongside this

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs10146997

What is rs10146997?

rs10146997 is a single position in the genome, in or near the NRXN3 gene. Published research associates it with waist circumference. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10146997 linked to?

On MyGeneLog this position is linked to Waist Circumference. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs10146997?

Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (3 papers), exercise and muscle (1 papers), risk-taking and impulsivity (1 papers), sleep and insomnia (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs10146997 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10146997 come from?

GWAS Catalog, PLoS Genet 2009, PMID:19557197. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Waist circumference (rs10146997). MyGeneLog™. https://www.mygenelog.com/variants/rs10146997

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