ZDHHC11 · rs2736098
Where this position leads
Condition: Pancreatic Cancer
Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
Strength of the evidence
Its strongest genetic-study result is p = 10−48, with 10 associations in the GWAS Catalog.
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 1,582 European ancestry cases, 5,203 European ancestry controls; replicated in 6,101 European ancestry cases, 9,194 European ancestry controls.
The effect Each copy of the C allele carried 1.25 times the odds of Pancreatic cancer (95% confidence interval 1.18-1.32); p = 1 × 10−13.
How common The C allele had a frequency of about 72% in the people studied.
Where it sits Chromosome 5, band 5p15.33 — a synonymous change in TERT.
What ClinVar records
Classification
Benign/Likely benign for Dyskeratosis congenita, autosomal dominant 1, Aplastic anemia, Pulmonary fibrosis and/or bone marrow failure, Telomere-related, 1, Dyskeratosis congenita, autosomal dominant 2, Idiopathic Pulmonary Fibrosis and 3 more; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 20 submitters), last evaluated 2026-02-04.
ClinVar record 39126 NM_198253.3(TERT):c.915G>A (p.Ala305=)
Classification
Likely benign for Dyskeratosis congenita; criteria provided, single submitter (1 of 4 stars, 1 submitter), last evaluated 2019-11-25.
ClinVar record 1766005 NM_198253.3(TERT):c.915G>T (p.Ala305=)
Change history MyGeneLog™ keeps a copy of every weekly release from 2026-10-19 and compares them. This position's classification has not changed since.
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
How common each version is
CT
C 68.6% · T 31.4%
C 69.2% · T 30.8%
C 74.6% · T 25.4%
C 54.0% · T 46.0%
C 77.8% · T 22.2%
C 73.4% · T 26.6%
C 78.6% · T 21.4%
The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
rs2736098 is a single position in the genome, in or near the ZDHHC11 gene. Published research associates it with pancreatic cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Pancreatic Cancer. The research behind each link, and its sources, are set out on that condition page.
Subjects that appear in the title or abstract of the same papers as this rsID include alcohol and the flush (3 papers), infection and immunity (2 papers), blood sugar and insulin (1 papers), longevity and ageing (1 papers), liver (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nat Genet 2014, PMID:25086665. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Pancreatic cancer (rs2736098). MyGeneLog™. https://www.mygenelog.com/variants/rs2736098