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Pancreatic cancer

ZDHHC11 · rs2736098

Where this position leads

Condition: Pancreatic Cancer

rs2736098 Condition: Pancreatic Cancer Pancreatic Cancer Condition Topic: Alcohol and the flush Alcohol and the flush Topic rs2736098 rs2736098 ZDHHC11

Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.

What the study found

Who was studied 1,582 European ancestry cases, 5,203 European ancestry controls; replicated in 6,101 European ancestry cases, 9,194 European ancestry controls.

The effect Each copy of the C allele carried 1.25 times the odds of Pancreatic cancer (95% confidence interval 1.18-1.32); p = 1 × 10−13.

How common The C allele had a frequency of about 72% in the people studied.

Where it sits Chromosome 5, band 5p15.33 — a synonymous change in TERT.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Pancreatic cancer compared to the general population.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Pancreatic cancer.
T/T Published research associates this genotype with typical/baseline likelihood of Pancreatic cancer — no copies of the reported risk allele.
Source
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer
Wolpin BM, Rizzato C, Kraft P, Kooperberg C, Petersen GM, Wang Z, Arslan AA, Beane-Freeman L, Bracci PM, Buring J, Canzian F, Duell EJ
and 106 more — show all
Gallinger S, Giles GG, Goodman GE, Goodman PJ, Jacobs EJ, Kamineni A, Klein AP, Kolonel LN, Kulke MH, Li D, Malats N, Olson SH, Risch HA, Sesso HD, Visvanathan K, White E, Zheng W, Zheng W, Abnet CC, Albanes D, Andreotti G, Austin MA, Barfield R, Basso D, Berndt SI, Boutron-Ruault MC, Brotzman M, Büchler MW, Bueno-de-Mesquita HB, Bugert P, Burdette L, Campa D, Caporaso NE, Capurso G, Chung C, Cotterchio M, Costello E, Elena J, Funel N, Gaziano JM, Giese NA, Giovannucci EL, Goggins M, Gorman MJ, Gross M, Haiman CA, Hassan M, Helzlsouer KJ, Henderson BE, Holly EA, Hu N, Hunter DJ, Innocenti F, Jenab M, Kaaks R, Key TJ, Khaw KT, Klein EA, Kogevinas M, Krogh V, Kupcinskas J, Kurtz RC, LaCroix A, Landi MT, Landi S, Le Marchand L, Mambrini A, Mannisto S, Milne RL, Nakamura Y, Oberg AL, Owzar K, Patel AV, Peeters PH, Peters U, Pezzilli R, Piepoli A, Porta M, Real FX, Riboli E, Rothman N, Scarpa A, Shu XO, Silverman DT, Soucek P, Sund M, Talar-Wojnarowska R, Taylor PR, Theodoropoulos GE, Thornquist M, Tjønneland A, Tobias GS, Trichopoulos D, Vodicka P, Wactawski-Wende J, Wentzensen N, Wu C, Yu H, Yu K, Zeleniuch-Jacquotte A, Hoover R, Hartge P, Fuchs C, Chanock SJ, Stolzenberg-Solomon RS, Amundadottir LT
Nature genetics · 2014 · PMID 25086665 · open access

What people read about alongside this

Alcohol and the flush3 Infection and immunity2 Blood sugar and insulin1 Longevity and ageing1 Liver1 Smoking and vaping1 Exercise and muscle1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs2736098

What is rs2736098?

rs2736098 is a single position in the genome, in or near the ZDHHC11 gene. Published research associates it with pancreatic cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs2736098 linked to?

On MyGeneLog this position is linked to Pancreatic Cancer. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs2736098?

Subjects that appear in the title or abstract of the same papers as this rsID include alcohol and the flush (3 papers), infection and immunity (2 papers), blood sugar and insulin (1 papers), longevity and ageing (1 papers), liver (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs2736098 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2736098 come from?

GWAS Catalog, Nat Genet 2014, PMID:25086665. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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