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Ulcerative colitis

DAP · rs267939

Where this position leads

Condition: Ulcerative Colitis

rs267939 Condition: Ulcerative Colitis Ulcerative Colitis Condition rs267939 rs267939 DAP

What the study found

Who was studied 6,687 European ancestry cases, 19,718 European ancestry controls; replicated in 9,628 European ancestry cases, 12,917 European ancestry controls.

The effect Each copy of the C allele carried 1.10 times the odds of Ulcerative colitis (95% confidence interval 1.06-1.15); p = 6 × 10−12.

How common The C allele had a frequency of about 37% in the people studied.

Where it sits Chromosome 5, band 5p15.2 — in an intron of DAP.

What each result means

C/C Two copies of the version the research linked to Ulcerative colitis. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Ulcerative colitis. That is a smaller link than two copies.
T/T No copy of the version the research linked to Ulcerative colitis. This is the starting point the study compared everyone against.
Source

What people read about alongside this

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs267939

What is rs267939?

rs267939 is a single position in the genome, in or near the DAP gene. Published research associates it with ulcerative colitis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs267939 linked to?

On MyGeneLog this position is linked to Ulcerative Colitis. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs267939?

Subjects that appear in the title or abstract of the same papers as this rsID include exercise and muscle (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs267939 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs267939 come from?

GWAS Catalog, Nat Genet 2011, PMID:21297633. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Ulcerative colitis (rs267939). MyGeneLog™. https://www.mygenelog.com/variants/rs267939

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