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Stands on its own.
Nothing else here links to this position yet — but the page above is the point: what the
research found, what each genotype means, and where it came from, in language you can
read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 10,701 European ancestry individuals; replicated in 16,378 European ancestry individuals.
The effect
The reported allele is A; the catalogue records no effect size
; p = 3 × 10−18.
How common The A allele had a frequency of about 69% in the people studied.
Where it sits Chromosome 8, band 8q24.11 — in the 3′ untranslated region of SLC30A8.
What each result means
A/ATwo copies of the version the research linked to Proinsulin levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Proinsulin levels. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Proinsulin levels. This is the starting point the study compared everyone against.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Gestational diabetes affects about 14% of pregnancies and raises the mother's later risk of type 2 diabetes. The GenDiP Consortium's meta-analysis covers up to 38,305 women with gestational diabetes and 776,145 controls and finds 37 associated loci, 7 of them new, plus five new loci for blood sugar traits in pregnancy — all acting through the mother's genome rather than the baby's. Every locus overlaps type 2 diabetes or glycaemic traits outside pregnancy, which is the 'limited evidence' of the title; but 12 variants have stronger effects in gestational diabetes than in type 2 diabetes, four loci (G6PC2, CAST-PCSK1, HKDC1, FOXA2) have no genome-wide-significant type 2 diabetes association, GCK shows distinct causal variants, and MTNR1B's effect is amplified in pregnancy. Seven of the study's positions are on this site under other traits, including rs560887 (G6PC2), rs11558471 (SLC30A8), rs849134 (JAZF1) and rs4665972 (GCKR). It sits beside this site's gestational diabetes page, which is built on a separate 2026 study. PMID:42225636.
Questions about rs11558471
What is rs11558471?
rs11558471 is a single position in the genome, in or near the SLC30A8 gene. Published research associates it with proinsulin levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What do people read about alongside rs11558471?
Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (13 papers), exercise and muscle (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs11558471 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs11558471 come from?
GWAS Catalog, Diabetes 2011, PMID:21873549. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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