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Opioid receptor sensitivity

OPRM1 · rs1799971

Where this position leads

Condition: Opioid Receptor Sensitivity (OPRM1)

Drug: Opioids

rs1799971 Condition: Opioid Receptor Sensitivity (OPRM1) Opioid Receptor Sensitivity (OPRM1) Condition Drug: Opioids Opioids Drug Topic: Alcohol and the flush Alcohol and the flush Topic Topic: Depression and stress Depression and stress Topic Topic: Smoking and vaping Smoking and vaping Topic rs1799971 rs1799971 OPRM1

Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.

What ClinVar records

Classification Uncertain significance; drug response for Opioid dependence, susceptibility to, 1, Tramadol response; no assertion criteria provided (0 of 4 stars, 2 submitters), last evaluated 2018-04-28. ClinVar record 9538 NM_000914.5(OPRM1):c.118A>G (p.Asn40Asp)

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

A/A Typical opioid receptor sensitivity in published research.
A/G Published research associates this genotype with somewhat altered opioid receptor sensitivity.
G/G Published research associates this genotype with altered opioid receptor sensitivity, which some studies link to differences in pain medication response.
This does not change how any medication should be prescribed. Talk to a doctor about pain management — never adjust medication on your own based on this result.
Source
Single-nucleotide polymorphism in the human mu opioid receptor gene alters beta-endorphin binding and activity: possible implications for opiate addiction
Bond C, LaForge KS, Tian M, Melia D, Zhang S, Borg L, Gong J, Schluger J, Strong JA, Leal SM, Tischfield JA, Kreek MJ
and 1 more — show all
Yu L
Proceedings of the National Academy of Sciences of the United States of America · 1998 · PMID 9689128

What people read about alongside this

Alcohol and the flush36 Depression and stress10 Smoking and vaping7 Anxiety and worry4 Exercise and muscle4 Risk-taking and impulsivity3 Learning and focus3 Personality2 ADHD and attention2 Sleep and insomnia2 Running and endurance2 Blood sugar and insulin1 Sport and performance1 Longevity and ageing1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs1799971

What is rs1799971?

rs1799971 is a single position in the genome, in or near the OPRM1 gene. Published research associates it with opioid receptor sensitivity. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1799971 linked to?

On MyGeneLog this position is linked to Opioid Receptor Sensitivity (OPRM1). The research behind each link, and its sources, are set out on that condition page.

Does rs1799971 affect how medicines work?

OPRM1 carries pharmacogenomic findings for Opioids. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

What do people read about alongside rs1799971?

Subjects that appear in the title or abstract of the same papers as this rsID include alcohol and the flush (36 papers), depression and stress (10 papers), smoking and vaping (7 papers), anxiety and worry (4 papers), exercise and muscle (4 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs1799971 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1799971 come from?

Bond et al. 1998, PNAS — single nucleotide polymorphism in the human mu opioid receptor gene. PMID 9689128. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Opioid receptor sensitivity (rs1799971). MyGeneLog™. https://www.mygenelog.com/variants/rs1799971

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