4 61110165222329Reads by AI crawlersClaude1ChatGPT10Google · Gemini1Perplexity6Meta AI5Microsoft · Copilot2Amazon2Apple2China (ByteDance, Huawei, Baidu…)3ByteDance (Doubao)3Others29Total61Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
What ClinVar records
Classificationdrug response for Phenylthiocarbamide tasting; no assertion criteria provided (0 of 4 stars, 1 submitter), last evaluated 2011-05-12.
ClinVar record 2906NM_176817.5(TAS2R38):c.886A>G (p.Ile296Val)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
C/CTwo copies of the allele that puts valine at position 296, the residue carried by the taster (PAV) form of the receptor. Published research associates this genotype with greater perceived bitterness from compounds such as PTC and PROP. This is one of three changes in TAS2R38 that are interpreted together — the others are rs713598 (position 49) and rs1726866 (position 262). The combination is what determines taster status, so a single one of the three is only part of the answer.
C/TOne copy of each. Published research associates this genotype with intermediate bitterness perception. This is one of three changes in TAS2R38 that are interpreted together — the others are rs713598 (position 49) and rs1726866 (position 262). The combination is what determines taster status, so a single one of the three is only part of the answer.
T/TTwo copies of the allele that puts isoleucine at position 296, the residue carried by the non-taster (AVI) form of the receptor. Published research associates this genotype with weaker perceived bitterness from these compounds. This is one of three changes in TAS2R38 that are interpreted together — the others are rs713598 (position 49) and rs1726866 (position 262). The combination is what determines taster status, so a single one of the three is only part of the answer.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs10246939
What is rs10246939?
rs10246939 is a single position in the genome, in or near the TAS2R38 gene. Published research associates it with bitter taste perception (tas2r38 position 296). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs10246939 linked to?
On MyGeneLog this position is linked to Bitter Taste Perception (TAS2R38), Chronic Rhinosinusitis and the Bitter Taste Receptor. The research behind each link, and its sources, are set out on that condition page.
Does rs10246939 affect how medicines work?
TAS2R38 carries pharmacogenomic findings for Bitter medicines. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does rs10246939 affect smell or taste?
This position sits in the Taste group on the chemosensory axis. Chemosensory variants do not shift a risk — they change the perception itself, which makes them the rarest thing on this site: genetics you can check on yourself.
What do people read about alongside rs10246939?
Subjects that appear in the title or abstract of the same papers as this rsID include smell and taste (9 papers), alcohol and the flush (4 papers), exercise and muscle (1 papers), fertility (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs10246939 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10246939 come from?
Bivariate GWAS of bitter taste perception (BMC Genomics 2018; PMID 30223776), 1,999 individuals of European ancestry from 929 twin families; p = 3 x 10^-199 — the strongest association on this site. Also found in a Brazilian cohort (Hum Mol Genet 2013; PMID 23966204). Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
4 61110165222329Reads by AI crawlersClaude1ChatGPT10Google · Gemini1Perplexity6Meta AI5Microsoft · Copilot2Amazon2Apple2China (ByteDance, Huawei, Baidu…)3ByteDance (Doubao)3Others29Total61Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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Bitter taste perception (TAS2R38 position 296) (rs10246939). MyGeneLog™. https://www.mygenelog.com/variants/rs10246939