ESR1 · rs2046210
Where this position leads
Condition: Breast Cancer
Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
What the study found
Who was studied 1,505 Chinese ancestry cases, 1,522 Chinese ancestry controls; replicated in 5,026 Chinese ancestry cases, 2,476 Chinese ancestry controls, 1,591 European ancestry cases, 1,466 European ancestry controls.
The effect Each copy of the A allele carried 1.29 times the odds of Breast cancer (95% confidence interval 1.21-1.37); p = 2 × 10−15.
How common The A allele had a frequency of about 37% in the people studied.
Where it sits Chromosome 6, band 6q25.1 — inside LOC124901435.
What ClinVar records
Classification
Benign for Estrogen resistance syndrome; criteria provided, single submitter (1 of 4 stars, 2 submitters), last evaluated 2020-10-28.
ClinVar record 155877 NC_000006.12:g.151627231G>A
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
rs2046210 is a single position in the genome, in or near the ESR1 gene. Published research associates it with breast cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Breast Cancer. The research behind each link, and its sources, are set out on that condition page.
Subjects that appear in the title or abstract of the same papers as this rsID include menopause (3 papers), alcohol and the flush (2 papers), vitamins and nutrient levels (1 papers), exercise and muscle (1 papers), fertility (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nat Genet 2009, PMID:19219042. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Breast cancer (rs2046210). MyGeneLog™. https://www.mygenelog.com/variants/rs2046210