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Bone mineral density (spine)

ZBTB40 · rs7524102

Where this position leads

Condition: Spine Bone Mineral Density

rs7524102 Condition: Spine Bone Mineral Density Spine Bone Mineral Density Condition Topic: Bones and fractures Bones and fractures Topic rs7524102 rs7524102 ZBTB40

Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.

What the study found

Who was studied 19,195 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.09 s.d. higher (95% confidence interval 0.06-0.12); p = 3 × 10−10.

How common The G allele had a frequency of about 17% in the people studied.

Where it sits Chromosome 1, band 1p36.12 — between genes, 44.4 kb from LOC105376856.

What each result means

A/A No copy of the version the research linked to Bone mineral density (spine). This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Bone mineral density (spine). That is a smaller link than two copies.
G/G Two copies of the version the research linked to Bone mineral density (spine). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies
Rivadeneira F, Styrkársdottir U, Estrada K, Halldórsson BV, Hsu YH, Richards JB, Zillikens MC, Kavvoura FK, Amin N, Aulchenko YS, Cupples LA, Deloukas P
and 23 more — show all
Demissie S, Grundberg E, Hofman A, Kong A, Karasik D, van Meurs JB, Oostra B, Pastinen T, Pols HA, Sigurdsson G, Soranzo N, Thorleifsson G, Thorsteinsdottir U, Williams FM, Wilson SG, Zhou Y, Ralston SH, van Duijn CM, Spector T, Kiel DP, Stefansson K, Ioannidis JP, Uitterlinden AG
Genetic Factors for Osteoporosis (GEFOS) Consortium
Nature genetics · 2009 · PMID 19801982 · open access

What people read about alongside this

Bones and fractures3 Exercise and muscle1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs7524102

What is rs7524102?

rs7524102 is a single position in the genome, in or near the ZBTB40 gene. Published research associates it with bone mineral density (spine). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs7524102 linked to?

On MyGeneLog this position is linked to Spine Bone Mineral Density. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs7524102?

Subjects that appear in the title or abstract of the same papers as this rsID include bones and fractures (3 papers), exercise and muscle (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs7524102 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs7524102 come from?

GWAS Catalog, Nat Genet 2009, PMID:19801982. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Bone mineral density (spine) (rs7524102). MyGeneLog™. https://www.mygenelog.com/variants/rs7524102

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