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Bone mineral density (spine)

ESR1 · rs4870044

Where this position leads

Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.

What the study found

Who was studied 5,861 European ancestry individuals; replicated in 7,925 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.11 s.d. lower (95% confidence interval 0.08-0.14); p = 2 × 10⁻¹¹.

How common The T allele had a frequency of about 28% in the people studied.

Where it sits Chromosome 6, band 6q25.1 — in an intron of CCDC170.

What each result means

C/C No copy of the version the research linked to Bone mineral density (spine). This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Bone mineral density (spine). That is a smaller link than two copies.

T/T Two copies of the version the research linked to Bone mineral density (spine). That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Multiple genetic loci for bone mineral density and fractures

Styrkarsdottir U, Halldorsson BV, Gretarsdottir S, Gudbjartsson DF, Walters GB, Ingvarsson T, Jonsdottir T, Saemundsdottir J, Center JR, Nguyen TV, Bagger Y, Gulcher JR

and 6 more — show all

Eisman JA, Christiansen C, Sigurdsson G, Kong A, Thorsteinsdottir U, Stefansson K

The New England journal of medicine · 2008 · PMID 18445777

What people read about alongside this

Bones and fractures5 Menopause2 Vitamins and nutrient levels2 Exercise and muscle1 Sport and performance1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs4870044

What is rs4870044?

rs4870044 is a single position in the genome, in or near the ESR1 gene. Published research associates it with bone mineral density (spine). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4870044 linked to?

On MyGeneLog this position is linked to Spine Bone Mineral Density. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs4870044?

Subjects that appear in the title or abstract of the same papers as this rsID include bones and fractures (5 papers), menopause (2 papers), vitamins and nutrient levels (2 papers), exercise and muscle (1 papers), sport and performance (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs4870044 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4870044 come from?

GWAS Catalog, N Engl J Med 2008, PMID:18445777. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Bone mineral density (spine) (rs4870044). MyGeneLog™. https://www.mygenelog.com/variants/rs4870044

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