LRP5 · rs3736228
Where this position leads
Condition: Heel Bone Mineral Density
Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
What the study found
Who was studied 2,094 European ancestry female individuals; replicated in 6,463 European ancestry individuals.
The effect Each copy of the T allele shifted the measure 0.13 SD lower; p = 6 × 10−12.
How common The T allele had a frequency of about 14% in the people studied.
Where it sits Chromosome 11, band 11q13.2 — a missense change in LRP5.
What ClinVar records
Classification
Benign for Osteoporosis with pseudoglioma, Osteogenesis imperfecta, Colorectal cancer, Uveal melanoma, Uterine carcinosarcoma and 2 more; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 13 submitters), last evaluated 2026-02-04.
ClinVar record 258640 NM_002335.4(LRP5):c.3989C>T (p.Ala1330Val)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
rs3736228 is a single position in the genome, in or near the LRP5 gene. Published research associates it with bone mineral density. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Heel Bone Mineral Density. The research behind each link, and its sources, are set out on that condition page.
Subjects that appear in the title or abstract of the same papers as this rsID include bones and fractures (29 papers), menopause (3 papers), blood sugar and insulin (3 papers), exercise and muscle (2 papers), sport and performance (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Lancet 2008, PMID:18455228. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Bone mineral density (rs3736228). MyGeneLog™. https://www.mygenelog.com/variants/rs3736228