TAS2R38 · rs713598
Where this position leads
Conditions: Bitter Taste Perception (TAS2R38), Chronic Rhinosinusitis and the Bitter Taste Receptor
Drug: Bitter medicines
Smell & taste: Taste — why the same food is not the same food
Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
What ClinVar records
Classification
drug response for Phenylthiocarbamide tasting; no assertion criteria provided (0 of 4 stars, 1 submitter), last evaluated 2010-12-30.
ClinVar record 2904 NM_176817.5(TAS2R38):c.145G>C (p.Ala49Pro)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
rs713598 is a single position in the genome, in or near the TAS2R38 gene. Published research associates it with bitter taste perception (ptc/prop tasting). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Bitter Taste Perception (TAS2R38), Chronic Rhinosinusitis and the Bitter Taste Receptor. The research behind each link, and its sources, are set out on that condition page.
TAS2R38 carries pharmacogenomic findings for Bitter medicines. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
This position sits in the Taste group on the chemosensory axis. Chemosensory variants do not shift a risk — they change the perception itself, which makes them the rarest thing on this site: genetics you can check on yourself.
Subjects that appear in the title or abstract of the same papers as this rsID include smell and taste (14 papers), alcohol and the flush (4 papers), sleep and insomnia (1 papers), blood sugar and insulin (1 papers), exercise and muscle (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Quinine taste intensity and a bitter receptor cluster on chromosome 12 (Hum Mol Genet 2010; PMID 20675712), 1,457 individuals of European ancestry; p = 2 x 10^-104. Read with rs1726866 (262) and rs10246939 (296) as one haplotype: Pro-Ala-Val tastes it, Ala-Val-Ile does not. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Bitter taste perception (PTC/PROP tasting) (rs713598). MyGeneLog™. https://www.mygenelog.com/variants/rs713598