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Adiposity

TFAP2B · rs987237

Where this position leads

Condition: Obesity and Body Weight

rs987237 Condition: Obesity and Body Weight Obesity and Body Weight Condition Topic: Blood sugar and insulin Blood sugar and insulin Topic Topic: Weight-loss medicines Weight-loss medicines Topic rs987237 rs987237 TFAP2B

Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.

What the study found

Who was studied 38,580 European ancestry individuals; replicated in Up to 102,064 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.04 z-score unit higher (95% confidence interval 0.03-0.05); p = 2 × 10−11.

How common The G allele had a frequency of about 16% in the people studied.

Where it sits Chromosome 6, band 6p12.3 — in an intron of TFAP2B.

What each result means

A/A No copy of the version the research linked to Adiposity. This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Adiposity. That is a smaller link than two copies.
G/G Two copies of the version the research linked to Adiposity. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

What people read about alongside this

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs987237

What is rs987237?

rs987237 is a single position in the genome, in or near the TFAP2B gene. Published research associates it with adiposity. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs987237 linked to?

On MyGeneLog this position is linked to Obesity and Body Weight. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs987237?

Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (3 papers), weight-loss medicines (3 papers), exercise and muscle (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs987237 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs987237 come from?

GWAS Catalog, PLoS Genet 2009, PMID:19557161. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Adiposity (rs987237). MyGeneLog™. https://www.mygenelog.com/variants/rs987237

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