Psoriasis or type 2 diabetes (trans-disease meta-analysis)(opposite effect)
PROX1 · rs340874
5 503228223226Reads by AI crawlersClaude3ChatGPT2Google · Gemini0Perplexity2Meta AI8Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others26Total50Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
What the study found
Who was studied 11,024 European ancestry psoriasis cases, 74,124 European ancestry diabetes cases, 840,342 European ancestry controls.
The effect
Each copy of the C allele carried 1.06 times the odds of Psoriasis or type 2 diabetes (trans-disease meta-analysis)(opposite effect) (95% confidence interval -); p = 3 × 10−8.
Where it sits Chromosome 1, band 1q32.3 — in a non-coding transcript of PROX1.
What each result means
C/CTwo copies of the version the research linked to Psoriasis or type 2 diabetes (trans-disease meta-analysis)(opposite effect). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Psoriasis or type 2 diabetes (trans-disease meta-analysis)(opposite effect). That is a smaller link than two copies.
T/TNo copy of the version the research linked to Psoriasis or type 2 diabetes (trans-disease meta-analysis)(opposite effect). This is the starting point the study compared everyone against.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs340874
What is rs340874?
rs340874 is a single position in the genome, in or near the PROX1 gene. Published research associates it with psoriasis or type 2 diabetes (trans-disease meta-analysis)(opposite effect). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs340874 linked to?
On MyGeneLog this position is linked to Psoriasis. The research behind each link, and its sources, are set out on that condition page.
What do people read about alongside rs340874?
Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (11 papers), exercise and muscle (2 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs340874 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs340874 come from?
GWAS Catalog, J Invest Dermatol 2020, PMID:33385400. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
5 503228223226Reads by AI crawlersClaude3ChatGPT2Google · Gemini0Perplexity2Meta AI8Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others26Total50Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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Psoriasis or type 2 diabetes (trans-disease meta-analysis)(opposite effect) (rs340874). MyGeneLog™. https://www.mygenelog.com/variants/rs340874