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Bones and fractures

Bone density is one of the more heritable things about a body — and the thing that actually matters, whether it breaks, is much harder to predict.

Why this topic Strength training became the default advice for everyone over forty, and the weight-loss drugs raised a question about what is lost along with the fat.

What this topic connects to

Bones and fractures Variant: rs3736228 rs3736228 Variant Variant: rs2282679 rs2282679 Variant Variant: rs1801133 rs1801133 Variant Variant: rs9939609 rs9939609 Variant Variant: rs4988235 rs4988235 Variant Variant: +42 more +42 more Variant Bones and fractures Bones and fractures

Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.

Variants that share a paper with this

Counted in Europe PMC, where the title or abstract names both this topic and that rsID. The number is papers, not evidence of a cause.

rs3736228

LRP5

Bone mineral density

29 papers →

rs2282679

GC

Vitamin D levels

14 papers →

rs1801133

MTHFR

Folate metabolism (MTHFR C677T)

10 papers →

rs9939609

FTO

Menarche (age at onset)

7 papers →

rs4988235

MCM6 / LCT

Lactose tolerance

6 papers →

rs671

ALDH2

Alcohol flush reaction

6 papers →

rs1800469

TGFB1

Colorectal cancer

5 papers →

rs4870044

ESR1

Bone mineral density (spine)

5 papers →

rs1021188

RANKL

Bone mineral density

4 papers →

rs1038304

ESR1

Bone mineral density (hip)

4 papers →

rs6265

BDNF

Smoking behavior

4 papers →

rs9930506

FTO

Obesity-related traits

4 papers →

rs11898505

SPTBN1

Bone mineral density (spine)

3 papers →

rs1421085

FTO

Obesity

3 papers →

rs1558902

FTO

Obesity

3 papers →

rs1799964

HLA-DQA2

Crohn's disease

3 papers →

rs1800437

GIPR

Obesity

3 papers →

rs3829251

NADSYN1

Vitamin D levels

3 papers →

rs7524102

ZBTB40

Bone mineral density (spine)

3 papers →

rs9923231

VKORC1

Warfarin sensitivity

3 papers →

rs10423928

GIPR

Obesity

2 papers →

rs1801131

MTHFR

Folate metabolism (MTHFR A1298C)

2 papers →

rs1815739

ACTN3

Muscle fiber type ("sprinter gene")

2 papers →

rs365990

MYH6

Electrocardiographic traits

2 papers →

rs8050136

FTO

Type 2 diabetes

2 papers →

rs1042725

HMGA2

Head circumference (infant)

1 paper →

rs11574914

CCL19

Rheumatoid arthritis

1 paper →

rs1172822

BRSK1

Menarche and menopause (age at onset)

1 paper →

rs11889341

STAT4

Systemic lupus erythematosus

1 paper →

rs12150660

SHBG

Testosterone levels

1 paper →

rs12568930

near ZBTB40

Inflammatory bowel disease

1 paper →

rs13182402

ALDH7A1

Osteoporosis

1 paper →

rs17249754

ATP2B1

Blood pressure

1 paper →

rs17251221

CASR

Calcium levels

1 paper →

rs17277546

CYP3A4

Metabolic traits

1 paper →

rs1805096

LEPR

C-reactive protein

1 paper →

rs1990760

IFIH1

Type 1 diabetes

1 paper →

rs2046210

ESR1

Breast cancer

1 paper →

rs2070600

AGER

Pulmonary function

1 paper →

rs2074356

C12orf51

Renal function-related traits (BUN)

1 paper →

rs2241880

ATG16L1

Crohn's disease

1 paper →

rs2896019

PARVB

Hematological and biochemical traits

1 paper →

rs4609139

C7orf58

Bone mineral density

1 paper →

rs494453

RAP1A

Osteoporosis-related phenotypes

1 paper →

rs603424

SCD

Metabolic traits

1 paper →

rs6726821

near GALNT3

Bone mineral density (paediatric, total body less head)

1 paper →

rs780094

GCKR

Uric acid levels

1 paper →

How this was counted

Europe PMC, title and abstract only, searched for “bone mineral density”, “osteoporosis”, “fracture risk” alongside each published rsID. Full text was not counted: it returns every paper with an rsID buried in a supplementary table. Recounted monthly.