Standard

Metabolic traits

CYP3A4 · rs17277546

Where this position leads

Condition: Blood Metabolite Levels

rs17277546 Condition: Blood Metabolite Levels Blood Metabolite Levels Condition rs17277546 rs17277546 CYP3A4

What the study found

Who was studied 2,820 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.476 lower; p = 9 × 10−40.

How common The A allele had a frequency of about 4% in the people studied.

Where it sits Chromosome 7, band 7q22.1 — in the 3′ untranslated region of TRIM4.

What each result means

A/A Two copies of the version the research linked to Metabolic traits. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Metabolic traits. That is a smaller link than two copies.
G/G No copy of the version the research linked to Metabolic traits. This is the starting point the study compared everyone against.
Source

What people read about alongside this

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs17277546

What is rs17277546?

rs17277546 is a single position in the genome, in or near the CYP3A4 gene. Published research associates it with metabolic traits. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs17277546 linked to?

On MyGeneLog this position is linked to Blood Metabolite Levels. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs17277546?

Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (2 papers), bones and fractures (1 papers), depression and stress (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs17277546 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs17277546 come from?

GWAS Catalog, Nature 2011, PMID:21886157. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Metabolic traits (rs17277546). MyGeneLog™. https://www.mygenelog.com/variants/rs17277546

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