4 5352136222129Reads by AI crawlersClaude5ChatGPT2Google · Gemini1Perplexity3Meta AI6Microsoft · Copilot2Amazon2Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others29Total53Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 2,038 European ancestry female individuals, 1,531 European ancestry male individuals; replicated in 5,595 European ancestry female individuals, 2,126 European ancestry male individuals.
The effect
The reported allele is C; the catalogue records no effect size
; p = 4 × 10−8.
How common The C allele had a frequency of about 24% in the people studied.
Where it sits Chromosome 1, band 1p13.2 — in a non-coding transcript of KRT18P57.
What each result means
C/CTwo copies of the version the research linked to Osteoporosis-related phenotypes. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Osteoporosis-related phenotypes. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Osteoporosis-related phenotypes. This is the starting point the study compared everyone against.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs494453
What is rs494453?
rs494453 is a single position in the genome, in or near the RAP1A gene. Published research associates it with osteoporosis-related phenotypes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs494453 linked to?
On MyGeneLog this position is linked to Osteoporosis. The research behind each link, and its sources, are set out on that condition page.
What do people read about alongside rs494453?
Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (1 papers), bones and fractures (1 papers), vitamins and nutrient levels (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs494453 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs494453 come from?
GWAS Catalog, PLoS Genet 2010, PMID:20548944. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
4 5352136222129Reads by AI crawlersClaude5ChatGPT2Google · Gemini1Perplexity3Meta AI6Microsoft · Copilot2Amazon2Apple2China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others29Total53Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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