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Menarche and menopause (age at onset)

BRSK1 · rs1172822

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 17,438 European ancestry female individuals.

The effect Each copy of the T allele shifted the measure 0.49 years lower (95% confidence interval 0.38-0.60); p = 2 × 10⁻¹⁹.

How common The T allele had a frequency of about 37% in the people studied.

Where it sits Chromosome 19, band 19q13.42 — in an intron of BRSK1.

What each result means

C/C No copy of the version the research linked to Menarche and menopause (age at onset). This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Menarche and menopause (age at onset). That is a smaller link than two copies.

T/T Two copies of the version the research linked to Menarche and menopause (age at onset). That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Genome-wide association studies identify loci associated with age at menarche and age at natural menopause

He C, Kraft P, Chen C, Buring JE, Paré G, Hankinson SE, Chanock SJ, Ridker PM, Hunter DJ, Chasman DI

Nature genetics · 2009 · PMID 19448621 · open access

What people read about alongside this

Menopause5 Bones and fractures1 Fertility1 Longevity and ageing1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs1172822

What is rs1172822?

rs1172822 is a single position in the genome, in or near the BRSK1 gene. Published research associates it with menarche and menopause (age at onset). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What do people read about alongside rs1172822?

Subjects that appear in the title or abstract of the same papers as this rsID include menopause (5 papers), bones and fractures (1 papers), fertility (1 papers), longevity and ageing (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs1172822 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1172822 come from?

GWAS Catalog, Nat Genet 2009, PMID:19448621. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Menarche and menopause (age at onset) (rs1172822). MyGeneLog™. https://www.mygenelog.com/variants/rs1172822

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