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Bone mineral density (hip)

ESR1 · rs1038304

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What the study found

Who was studied 6,865 European ancestry individuals; replicated in 8,510 European ancestry individuals.

The effect Each copy of the G allele shifted the measure 0.08 s.d. lower (95% confidence interval 0.06-0.11); p = 4 × 10⁻¹⁰.

How common The G allele had a frequency of about 47% in the people studied.

Where it sits Chromosome 6, band 6q25.1 — in an intron of CCDC170.

What each result means

A/A No copy of the version the research linked to Bone mineral density (hip). This is the starting point the study compared everyone against.

A/G One copy of the version the research linked to Bone mineral density (hip). That is a smaller link than two copies.

G/G Two copies of the version the research linked to Bone mineral density (hip). That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

New sequence variants associated with bone mineral density

Styrkarsdottir U, Halldorsson BV, Gretarsdottir S, Gudbjartsson DF, Walters GB, Ingvarsson T, Jonsdottir T, Saemundsdottir J, Snorradóttir S, Center JR, Nguyen TV, Alexandersen P

and 7 more — show all

Gulcher JR, Eisman JA, Christiansen C, Sigurdsson G, Kong A, Thorsteinsdottir U, Stefansson K

Nature genetics · 2009 · PMID 19079262

What people read about alongside this

Bones and fractures4 Menopause1 Vitamins and nutrient levels1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs1038304

What is rs1038304?

rs1038304 is a single position in the genome, in or near the ESR1 gene. Published research associates it with bone mineral density (hip). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What do people read about alongside rs1038304?

Subjects that appear in the title or abstract of the same papers as this rsID include bones and fractures (4 papers), menopause (1 papers), vitamins and nutrient levels (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs1038304 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1038304 come from?

GWAS Catalog, Nat Genet 2008, PMID:19079262. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Bone mineral density (hip) (rs1038304). MyGeneLog™. https://www.mygenelog.com/variants/rs1038304

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