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Bone mineral density (spine)

SPTBN1 · rs11898505

Where this position leads

Condition: Spine Bone Mineral Density

rs11898505 Condition: Spine Bone Mineral Density Spine Bone Mineral Density Condition Topic: Bones and fractures Bones and fractures Topic rs11898505 rs11898505 SPTBN1

Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.

What the study found

Who was studied 19,195 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.07 s.d. higher (95% confidence interval 0.05-0.09); p = 2 × 10−8.

How common The A allele had a frequency of about 34% in the people studied.

Where it sits Chromosome 2, band 2p16.2 — in an intron of SPTBN1.

What each result means

A/A Two copies of the version the research linked to Bone mineral density (spine). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Bone mineral density (spine). That is a smaller link than two copies.
G/G No copy of the version the research linked to Bone mineral density (spine). This is the starting point the study compared everyone against.
Source

What people read about alongside this

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs11898505

What is rs11898505?

rs11898505 is a single position in the genome, in or near the SPTBN1 gene. Published research associates it with bone mineral density (spine). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11898505 linked to?

On MyGeneLog this position is linked to Spine Bone Mineral Density. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs11898505?

Subjects that appear in the title or abstract of the same papers as this rsID include bones and fractures (3 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs11898505 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11898505 come from?

GWAS Catalog, Nat Genet 2009, PMID:19801982. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Bone mineral density (spine) (rs11898505). MyGeneLog™. https://www.mygenelog.com/variants/rs11898505

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