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Bone mineral density

RANKL · rs1021188

Where this position leads

Condition: Heel Bone Mineral Density

rs1021188 Condition: Heel Bone Mineral Density Heel Bone Mineral Density Condition Topic: Bones and fractures Bones and fractures Topic rs1021188 rs1021188 RANKL

Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.

What the study found

Who was studied 1,934 European ancestry individuals; replicated in Up to 3,835 European ancestry individuals.

The effect Each copy of the C allele shifted the measure 3.89 mg/cm3 lower (95% confidence interval 1.91-5.87); p = 2 × 10−14.

How common The C allele had a frequency of about 18% in the people studied.

Where it sits Chromosome 13, band 13q14.11 — between genes, 20.7 kb from TNFSF11.

What each result means

C/C Two copies of the version the research linked to Bone mineral density. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Bone mineral density. That is a smaller link than two copies.
T/T No copy of the version the research linked to Bone mineral density. This is the starting point the study compared everyone against.
Source
Genome-wide association meta-analysis of cortical bone mineral density unravels allelic heterogeneity at the RANKL locus and potential pleiotropic effects on bone
Paternoster L, Lorentzon M, Vandenput L, Karlsson MK, Ljunggren O, Kindmark A, Mellstrom D, Kemp JP, Jarett CE, Holly JM, Sayers A, St Pourcain B
and 7 more — show all
Timpson NJ, Deloukas P, Davey Smith G, Ring SM, Evans DM, Tobias JH, Ohlsson C
PLoS genetics · 2010 · PMID 21124946 · open access

What people read about alongside this

Bones and fractures4 Sport and performance1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs1021188

What is rs1021188?

rs1021188 is a single position in the genome, in or near the RANKL gene. Published research associates it with bone mineral density. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1021188 linked to?

On MyGeneLog this position is linked to Heel Bone Mineral Density. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs1021188?

Subjects that appear in the title or abstract of the same papers as this rsID include bones and fractures (4 papers), sport and performance (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs1021188 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1021188 come from?

GWAS Catalog, PLoS Genet 2010, PMID:21124946. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Bone mineral density (rs1021188). MyGeneLog™. https://www.mygenelog.com/variants/rs1021188

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