Why this topic Burnout stopped being a workplace word and became a personal one.
In the news
2026-07-28 · Bright U, et al., Nature Communications 2026, PMID:42521668
Fibromyalgia shares much of its genetics with depression and PTSD
A genome-wide study of fibromyalgia (85,139 cases) found strong genetic correlations with chronic pain, post-traumatic stress disorder and depression — the clearest sign yet that the chronic pain syndrome and mood disorders draw on shared biology. 16 of its positions have pages on this site.
From our blog
What this topic connects to
Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
Variants that share a paper with this
Counted in Europe PMC, where the title or abstract names both this topic and that rsID. The number is papers, not evidence of a cause.
rs6265
BDNF
Smoking behavior
94 papers →rs1006737
CACNA1C
Schizophrenia
16 papers →rs1799971
OPRM1
Opioid receptor sensitivity
10 papers →rs1801133
MTHFR
Folate metabolism (MTHFR C677T)
10 papers →rs1801131
MTHFR
Folate metabolism (MTHFR A1298C)
8 papers →rs429358
APOE
Lewy body disease
6 papers →rs7103411
BDNP
Menarche (age at onset)
5 papers →rs1421085
FTO
Obesity
4 papers →rs1799964
HLA-DQA2
Crohn's disease
4 papers →rs671
ALDH2
Alcohol flush reaction
4 papers →rs4244285
CYP2C19
CYP2C19 *2 — clopidogrel activation
3 papers →rs762551
CYP1A2
Caffeine metabolism
3 papers →rs10507274
C12orf49
Neuroticism
2 papers →rs10994336
ANK3
Bipolar disorder
2 papers →rs11030104
BDNF
Body mass index
2 papers →rs12248560
CYP2C19
CYP2C19 *17 — increased enzyme activity
2 papers →rs1339227
RIMS1
Schizophrenia
2 papers →rs17319721
SHROOM3
Renal function and chronic kidney disease
2 papers →rs365990
MYH6
Electrocardiographic traits
2 papers →rs4986893
CYP2C19
CYP2C19 *3 — clopidogrel activation
2 papers →rs9939609
FTO
Menarche (age at onset)
2 papers →rs102275
FADS1
Crohn's disease
1 paper →rs1042602
TYR
Skin pigmentation
1 paper →rs1051730
CHRNA3
Smoking behavior
1 paper →rs1064395
NCAN
Bipolar disorder
1 paper →rs10738760
KCNV2
Vascular endothelial growth factor levels
1 paper →rs10994359
ANK3
Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined)
1 paper →rs11098403
NDST3
Schizophrenia
1 paper →rs11154801
AHI1
Multiple sclerosis
1 paper →rs11671664
GIPR
Body mass index (SNP x SNP interaction)
1 paper →rs11682175
FANCL
Schizophrenia
1 paper →rs1183910
HNF1A
C-reactive protein levels
1 paper →rs12129573
LRRIQ3
Schizophrenia
1 paper →rs1229984
ADH1B
Alcohol metabolism speed
1 paper →rs12807809
NRGN
Schizophrenia
1 paper →rs17277546
CYP3A4
Metabolic traits
1 paper →rs17367504
NPPA
Systolic blood pressure
1 paper →rs174546
FADS1
HDL cholesterol
1 paper →rs174547
FADS1
Metabolite levels
1 paper →rs1800469
TGFB1
Colorectal cancer
1 paper →rs1803274
BCHE
Cardiovascular disease risk factors
1 paper →rs1834481
BCO2
Interleukin-18 levels
1 paper →rs2074356
C12orf51
Renal function-related traits (BUN)
1 paper →rs2075650
APOE
Alzheimer's disease (late onset)
1 paper →rs2287019
GIPR
Body mass index
1 paper →rs2736100
TERT
Lung adenocarcinoma
1 paper →rs34637584
LRRK2
Parkinson's disease
1 paper →rs4420638
APOE
LDL cholesterol
1 paper →rs445
CDK6
White blood cell count
1 paper →rs4523957
SGSM2
Schizophrenia
1 paper →rs505922
ABO
Pancreatic cancer
1 paper →rs6484218
ADM
Schizophrenia, bipolar disorder and depression (combined)
1 paper →rs6855911
GLUT9
Urate levels
1 paper →rs6993770
ZFPM2
Vascular endothelial growth factor levels
1 paper →rs75059851
IGSF9B
Schizophrenia
1 paper →rs7596038
VRK2
Schizophrenia
1 paper →rs9834970
TRANK1
Bipolar disorder
1 paper →How this was counted
Europe PMC, title and abstract only, searched for “major depressive disorder”, “depressive symptoms”, “neuroticism”, “perceived stress” alongside each published rsID. Full text was not counted: it returns every paper with an rsID buried in a supplementary table. Recounted monthly.
Quoting this page
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Depression and stress. MyGeneLog™. https://www.mygenelog.com/topics/depression
Questions about Depression and stress
What is Depression and stress?
Depression and stress is this site's topic page for mood genetics — the field that taught genetics its hardest lesson about single genes, after decades of candidate-gene findings for depression failed to replicate.
Does a single gene cause depression?
No. Depression genetics is the field that taught researchers their hardest lesson about single genes: candidate genes once blamed for it did not hold up, and what remains is spread across many small-effect variants.
Why is depression and stress a topic on this site now?
Burnout stopped being a workplace word and became a personal one, which is why the genetics behind depression and everyday stress earned its own page this year.
How does this site decide which variants are linked to depression and stress?
Europe PMC is searched for major depressive disorder, depressive symptoms, neuroticism or perceived stress appearing in a paper's title or abstract alongside a published rsID, recounted every month.