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Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
What the study found
Who was studied 4,387 European ancestry cases, 6,209 European ancestry controls.
The effect
Each copy of the T allele carried 1.45 times the odds of Bipolar disorder; p = 9 × 10−9.
How common The T allele had a frequency of about 5% in the people studied.
Where it sits Chromosome 10, band 10q21.2 — in an intron of ANK3.
What each result means
C/CNo copy of the version the research linked to Bipolar disorder. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Bipolar disorder. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Bipolar disorder. That is the strongest link of the three results. A link in a study is not a diagnosis.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs10994336
What is rs10994336?
rs10994336 is a single position in the genome, in or near the ANK3 gene. Published research associates it with bipolar disorder. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs10994336 linked to?
On MyGeneLog this position is linked to Bipolar Disorder. The research behind each link, and its sources, are set out on that condition page.
What do people read about alongside rs10994336?
Subjects that appear in the title or abstract of the same papers as this rsID include learning and focus (4 papers), brain and memory (3 papers), depression and stress (2 papers), risk-taking and impulsivity (1 papers), alcohol and the flush (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs10994336 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10994336 come from?
GWAS Catalog, Nat Genet 2008, PMID:18711365. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
3 4932135222227Reads by AI crawlersClaude3ChatGPT2Google · Gemini1Perplexity3Meta AI5Microsoft · Copilot2Amazon2Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others27Total49Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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