TYR · rs1042602
Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.
What the study found
Who was studied 363 South Asian ancestry low maxL* individuals, 374 South Asian ancestry high maxL* individuals; replicated in 116 South Asian ancestry low maxL* individuals, 115 South Asian ancestry high maxL* individuals.
The effect Each copy of the C allele carried 4.36 times the odds of Skin pigmentation (95% confidence interval 2.64-7.20); p = 4 × 10−10.
How common The C allele had a frequency of about 84% in the people studied.
Where it sits Chromosome 11, band 11q14.3 — a missense change in TYR.
What ClinVar records
Classification
Conflicting classifications of pathogenicity for SKIN/HAIR/EYE PIGMENTATION 3, LIGHT/DARK SKIN, Oculocutaneous albinism type 1A, Oculocutaneous albinism, Oculocutaneous albinism type 1B, Albinism or congenital nystagmus and 1 more; criteria provided, conflicting classifications (1 of 4 stars, 24 submitters), last evaluated 2026-07-01.
ClinVar record 3778 NM_000372.5(TYR):c.575C>A (p.Ser192Tyr)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
rs1042602 is a single position in the genome, in or near the TYR gene. Published research associates it with skin pigmentation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Subjects that appear in the title or abstract of the same papers as this rsID include skin, sun and hair (8 papers), anxiety and worry (1 papers), depression and stress (1 papers), natural selection (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Am J Hum Genet 2007, PMID:17999355. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Skin pigmentation (rs1042602). MyGeneLog™. https://www.mygenelog.com/variants/rs1042602