LRRK2 · rs34637584
Where this position leads
Condition: Parkinson's Disease
Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
What the study found
Who was studied 3,426 European ancestry cases, 29,624 European ancestry controls.
The effect Each copy of the A allele carried 9.62 times the odds of Parkinson's disease (95% confidence interval 6.43-14.37); p = 2 × 10−28.
How common The A allele had a frequency of about 0% in the people studied.
Where it sits Chromosome 12, band 12q12 — a missense change in LRRK2.
What ClinVar records
Classification
Pathogenic/Likely pathogenic; risk factor for Autosomal dominant Parkinson disease 8, Inborn genetic diseases, Young-onset Parkinson disease, Parkinson disease, late-onset, LRRK2-related disorder and 1 more; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 29 submitters), last evaluated 2026-04-24.
ClinVar record 1940 NM_198578.4(LRRK2):c.6055G>A (p.Gly2019Ser)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
rs34637584 is a single position in the genome, in or near the LRRK2 gene. Published research associates it with parkinson's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Parkinson's Disease. The research behind each link, and its sources, are set out on that condition page.
Subjects that appear in the title or abstract of the same papers as this rsID include brain and memory (4 papers), adhd and attention (2 papers), depression and stress (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, PLoS Genet 2011, PMID:21738487. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Parkinson's disease (rs34637584). MyGeneLog™. https://www.mygenelog.com/variants/rs34637584