SHROOM3 · rs17319721
Where this position leads
Condition: Kidney Function
Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
What the study found
Who was studied 2,388 European ancestry cases, 17,489 European ancestry controls; replicated in 1,932 cases, 19,534 controls.
The effect Each copy of the A allele shifted the measure 0.01 ml/min/1.73m2 lower (95% confidence interval 0.008-0.016); p = 1 × 10−12.
How common The A allele had a frequency of about 44% in the people studied.
Where it sits Chromosome 4, band 4q21.1 — in an intron of SHROOM3.
What ClinVar records
Classification
Benign; criteria provided, single submitter (1 of 4 stars, 1 submitter), last evaluated 2018-07-13.
ClinVar record 1263431 NM_020859.4(SHROOM3):c.168+11474G>A
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
rs17319721 is a single position in the genome, in or near the SHROOM3 gene. Published research associates it with renal function and chronic kidney disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Kidney Function. The research behind each link, and its sources, are set out on that condition page.
Subjects that appear in the title or abstract of the same papers as this rsID include kidneys (11 papers), blood sugar and insulin (2 papers), depression and stress (2 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nat Genet 2009, PMID:19430482. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Renal function and chronic kidney disease (rs17319721). MyGeneLog™. https://www.mygenelog.com/variants/rs17319721