흔한 질환 중 가장 많이 연구된 것이고, 유전학이 찾아낸 것과 결과를 바꾸는 것 사이의 간격이 가장 넓은 것이기도 합니다. 수백 개 자리가 제2형 당뇨병과 연관되어 있는데, 그것을 다 합쳐도 누가 걸릴지에 대해 허리둘레와 가족력보다 적게 예측합니다.
이 토픽을 다루는 이유 연속혈당측정기가 예전에는 일 년에 한 번 보던 숫자를 몇 분마다 눈앞에 들이밀었고, 그다음에 오는 질문은 언제나 그 숫자가 물려받은 것이냐입니다. 대개는 아닙니다. 이 병이 몇 배로 흔해진 기간 내내 같은 유전자가 그 집단 안에 있었습니다.
출처: Mahajan 외, Nature Genetics 2018 — 제2형 당뇨병 유전자좌 정밀 지도
실선은 이 사이트가 검토해 연결한 관계입니다. 점선은 양쪽이 같은 논문에 함께 등장했다는 뜻입니다. 알아 둘 만하지만 한쪽이 다른 쪽을 설명한다는 주장은 아닙니다.
Europe PMC에서 제목이나 초록에 이 토픽과 해당 rsID를 함께 담은 논문을 셌습니다. 숫자는 논문 수이며 인과의 근거가 아닙니다.
FTO
Menarche (age at onset)
논문 95편 →KCNQ1
Type 2 diabetes
논문 73편 →FTO
Type 2 diabetes
논문 65편 →GCKR
Uric acid levels
논문 64편 →TCF7L2
Type 2 diabetes
논문 46편 →MTHFR
Folate metabolism (MTHFR C677T)
논문 34편 →KCNQ1
Type 2 diabetes
논문 31편 →IGF2BP2
Type 2 diabetes
논문 27편 →GCK
Glycated hemoglobin levels
논문 27편 →G6PC2
Fasting plasma glucose
논문 27편 →JAZF1
Type 2 diabetes
논문 26편 →FTO
Obesity
논문 25편 →APOE
Lewy body disease
논문 23편 →ADIPOQ
Adiponectin levels
논문 21편 →KCNJ11
Type 2 diabetes
논문 21편 →MC4R
Waist circumference and related phenotypes
논문 19편 →ATM
Response to metformin in type 2 diabetes (glycemic)
논문 18편 →BDNF
Smoking behavior
논문 18편 →THADA
Type 2 diabetes
논문 17편 →APOA5
Triglyceride levels
논문 16편 →ADCY5
Body mass index and fasting glucose (pairwise)
논문 15편 →LGR5
Type 2 diabetes
논문 15편 →GNPDA2
Obesity
논문 13편 →SLC30A8
Proinsulin levels
논문 13편 →AGER
Pulmonary function
논문 13편 →GC
Vitamin D levels
논문 13편 →MCM6 / LCT
Lactose tolerance
논문 13편 →ICAM1
Soluble ICAM-1
논문 13편 →IL29
Chronic hepatitis C infection
논문 13편 →NOTCH2
Type 2 diabetes
논문 12편 →GIPR
Obesity
논문 12편 →ALDH2
Alcohol flush reaction
논문 12편 →GIPR
Obesity
논문 11편 →CENTD2
Type 2 diabetes
논문 11편 →MTHFR
Folate metabolism (MTHFR A1298C)
논문 11편 →PROX1
Psoriasis or type 2 diabetes (trans-disease meta-analysis)(opposite effect)
논문 11편 →FTH1
Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid)
논문 10편 →ABCA1
HDL cholesterol
논문 10편 →ZNF259
Triglyceride levels
논문 10편 →FTO
Obesity
논문 9편 →KCNQ1
Type 2 diabetes
논문 9편 →SLCO1B1
Statin muscle-side-effect risk
논문 9편 →GRK5
Type 2 diabetes
논문 8편 →PCSK1
Proinsulin levels
논문 8편 →CYP1A2
Caffeine metabolism
논문 8편 →VEGFA
Thyroid hormone levels
논문 8편 →ADH1B
Alcohol metabolism speed
논문 7편 →C12orf51
Renal function-related traits (BUN)
논문 7편 →APOE
LDL cholesterol
논문 7편 →LPA
Cholesterol, total
논문 6편 →TGFB1
Colorectal cancer
논문 6편 →HNF4A
C-reactive protein levels
논문 6편 →SLC30A8
Type 2 diabetes
논문 6편 →CDKAL1
Type 2 diabetes
논문 6편 →DUSP9
Type 2 diabetes
논문 6편 →FTO
Obesity-related traits
논문 6편 →LPA
Parental lifespan (LPA, lipoprotein(a))
논문 5편 →MTCH2
Body mass index
논문 5편 →ADIPOQ
Adiponectin levels
논문 5편 →ADIPOQ
Adiponectin levels
논문 5편 →FADS1
Metabolite levels
논문 5편 →HLA-DQA2
Crohn's disease
논문 5편 →NPPB
B-type natriuretic peptide levels
논문 5편 →CETP
HDL cholesterol
논문 5편 →EDN1
Circulating vasoactive peptide levels
논문 5편 →APOB
Cholesterol, total
논문 5편 →IRS1
Modified Stumvoll Insulin Sensitivity Index (model adjusted for BMI)
논문 5편 →NCAN
LDL cholesterol
논문 4편 →G6PD
G6PD deficiency (G6PD A-)
논문 4편 →CDC123
Type 2 diabetes
논문 4편 →ADIPOQ
Adiponectin levels
논문 4편 →HFE
Iron overload risk (hereditary hemochromatosis)
논문 4편 →LPL
Metabolic syndrome
논문 4편 →AGR3
Urinary albumin excretion
논문 4편 →ANKRD55
Waist-to-hip ratio adjusted for body mass index
논문 4편 →HNF4A
Type 2 diabetes
논문 4편 →near MC4R
Childhood obesity
논문 4편 →TMEM154
Type 2 diabetes
논문 4편 →HNF1A
Type 2 diabetes
논문 4편 →NRXN3
Waist circumference
논문 3편 →COBLL1
Triglycerides
논문 3편 →KCNV2
Vascular endothelial growth factor levels
논문 3편 →ZFAND6
Type 2 diabetes
논문 3편 →SLC2A9
Urate levels
논문 3편 →MYL2
Alcohol consumption
논문 3편 →TERC
Telomere length
논문 3편 →ZFP36L2
Polycystic ovary syndrome
논문 3편 →FAF1
Type 2 diabetes
논문 3편 →FADS1
HDL cholesterol
논문 3편 →FADS2
QT interval
논문 3편 →HFE
Iron overload risk (HFE H63D)
논문 3편 →LEPR
C-reactive protein
논문 3편 →ARID3B
Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio)
논문 3편 →PCSK9
LDL cholesterol
논문 3편 →IRS1
Triglycerides
논문 3편 →CCR5
HIV-1 resistance (CCR5-delta32)
논문 3편 →LRP5
Bone mineral density
논문 3편 →ACE
Angiotensin-converting enzyme activity
논문 3편 →GALNT2
HDL cholesterol
논문 3편 →GHSR
Height
논문 3편 →IGF2BP2
Type 2 diabetes
논문 3편 →SFRS10
Body mass index
논문 3편 →GCKR
Crohn's disease
논문 3편 →UGT1A1
Bilirubin levels
논문 3편 →CDKAL1
Body mass index
논문 3편 →TFAP2B
Adiposity
논문 3편 →FN3K
Glycated hemoglobin levels
논문 2편 →GLIS3
Type 2 diabetes
논문 2편 →DENND1A
Polycystic ovary syndrome
논문 2편 →CDKN2A
Type 2 diabetes
논문 2편 →LINGO2
Obesity
논문 2편 →IL23R
Crohn's disease
논문 2편 →HNF1A
C-reactive protein levels
논문 2편 →DOCK7
Triglycerides
논문 2편 →CNNM2
Intracranial aneurysm
논문 2편 →MCTP2
Type 1 diabetes nephropathy
논문 2편 →ZMIZ1
Type 2 diabetes
논문 2편 →KCNQ1
QT interval
논문 2편 →CELSR2
LDL cholesterol
논문 2편 →MC1R
Hair color
논문 2편 →SLC2A9
Urate levels
논문 2편 →COBLL1
Waist-hip ratio
논문 2편 →CUBN
Urinary albumin excretion
논문 2편 →c10orf107
Diastolic blood pressure
논문 2편 →HK1
Hemoglobin
논문 2편 →PHB
Diastolic blood pressure
논문 2편 →CYP3A4
Metabolic traits
논문 2편 →SHROOM3
Renal function and chronic kidney disease
논문 2편 →NPPA
Systolic blood pressure
논문 2편 →KIAA0825
Diabetic retinopathy
논문 2편 →BCO2
Interleukin-18 levels
논문 2편 →IFIH1
Type 1 diabetes
논문 2편 →HPR
LDL cholesterol
논문 2편 →HDAC9
Stroke (ischemic)
논문 2편 →MAP2K5
Body mass index
논문 2편 →ATG16L1
Crohn's disease
논문 2편 →GIPR
Body mass index
논문 2편 →CETP
HDL cholesterol
논문 2편 →LYPLAL1
Adiposity
논문 2편 →LEF1
Metabolic traits
논문 2편 →RABEP2
Inflammatory bowel disease
논문 2편 →ATP2B1
Hypertension
논문 2편 →PARVB
Hematological and biochemical traits
논문 2편 →TRIB1
Triglycerides
논문 2편 →ICAM-1
Soluble levels of adhesion molecules
논문 2편 →LPA
Coronary heart disease
논문 2편 →POU2AF3
Colorectal cancer
논문 2편 →CAV1
PR interval
논문 2편 →MLXIPL
Triglycerides
논문 2편 →ADAMTS7
Coronary heart disease
논문 2편 →APOC2
Triglycerides
논문 2편 →SGSM2
Schizophrenia
논문 2편 →GGT1
Liver enzyme levels
논문 2편 →CYP2C19
CYP2C19 *3 — clopidogrel activation
논문 2편 →ABO
Pancreatic cancer
논문 2편 →MBOAT7
Cirrhosis (alcohol related)
논문 2편 →LDLR
Lipoprotein-associated phospholipase A2 activity and mass
논문 2편 →HSD17B13
Liver enzyme levels (alanine transaminase)
논문 2편 →PVRL2
Dementia and core Alzheimer's disease neuropathologic changes
논문 2편 →POU5F1B
Prostate cancer
논문 2편 →CSNK2A2
Telomere length
논문 2편 →AFF3
Type 1 diabetes nephropathy
논문 2편 →CYP3A5
CYP3A5 expression (*3 allele)
논문 2편 →JAZF1
Type 2 diabetes
논문 2편 →FTO
Type 2 diabetes
논문 2편 →PITX2
Atrial fibrillation/atrial flutter
논문 1편 →CDKN2A
Breast cancer
논문 1편 →NFE2L3
Waist-to-hip ratio adjusted for body mass index
논문 1편 →APOB
Triglycerides
논문 1편 →HMGA2
Head circumference (infant)
논문 1편 →LIPC
HDL cholesterol
논문 1편 →FN3K
Glycated hemoglobin levels
논문 1편 →CPS1
Plasma homocysteine levels (post-methionine load test)
논문 1편 →C6orf57
Type 2 diabetes
논문 1편 →TNFAIP3
Rheumatoid arthritis
논문 1편 →near RBPJ
Type 1 diabetes
논문 1편 →LIG3
QT interval
논문 1편 →PGPEP1
Growth differentiation factor-15 levels
논문 1편 →NFE2L3
Waist-hip ratio
논문 1편 →GATA3
Colorectal cancer
논문 1편 →LPA
HDL cholesterol
논문 1편 →BDNF
Body mass index
논문 1편 →TRAFD1
Hemoglobin
논문 1편 →ACAD10
Esophageal cancer
논문 1편 →INHBC
Urate levels
논문 1편 →HHEX
Multiple sclerosis
논문 1편 →NT5C2
Systolic blood pressure
논문 1편 →TPMT
TPMT *3C — thiopurine tolerance
논문 1편 →MUC19
Crohn's disease
논문 1편 →CAV1/2
Atrial fibrillation
논문 1편 →STAT4
Systemic lupus erythematosus
논문 1편 →NOS1AP
QT interval
논문 1편 →FTO
Body mass index (SNP x SNP interaction)
논문 1편 →SHBG
Testosterone levels
논문 1편 →IRF4
Freckling & sun sensitivity
논문 1편 →near PLXDC2
Diabetic retinopathy
논문 1편 →APOC3
Triglycerides
논문 1편 →NTRK2
Birth weight
논문 1편 →GPRC5B
Obesity
논문 1편 →ZFP36L2
Polycystic ovary syndrome
논문 1편 →HHIP
Pulmonary function
논문 1편 →PHACTR1
Coronary heart disease
논문 1편 →KIAA0350
Type 1 diabetes
논문 1편 →RASD1
Coronary heart disease
논문 1편 →ACBD4
Systolic blood pressure
논문 1편 →CADM2
Obesity
논문 1편 →NUCB2
Height
논문 1편 →LINGO2
Obesity
논문 1편 →CUBN
Urinary albumin excretion
논문 1편 →KCNK9
Menarche (age at onset)
논문 1편 →THNSL2
Visceral fat
논문 1편 →near SCG5
Colorectal cancer
논문 1편 →SC4MOL
Insulin-related traits
논문 1편 →MSRB3
Hippocampal volume
논문 1편 →ATP2B1
Blood pressure
논문 1편 →CASR
Calcium levels
논문 1편 →CETP
HDL Cholesterol - Triglycerides (HDLC-TG)
논문 1편 →CXCL12
Myocardial infarction (early onset)
논문 1편 →GOSR2
QRS duration
논문 1편 →BHMT2
Metabolite levels
논문 1편 →ICAM1
Soluble ICAM-1
논문 1편 →OPRM1
Opioid receptor sensitivity
논문 1편 →ACTN3
Muscle fiber type ("sprinter gene")
논문 1편 →ACADS
Metabolite levels
논문 1편 →LIPC
Lipid traits
논문 1편 →HMGA1
Body mass index
논문 1편 →OAS3
Alcohol consumption
논문 1편 →CYP7A1
Cholesterol, total
논문 1편 →IL6
C-reactive protein
논문 1편 →PHB2
Red blood cell fatty acid levels
논문 1편 →C5orf37
Obesity
논문 1편 →BCO2
Interleukin-18 levels
논문 1편 →ELOVL2
Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid)
논문 1편 →MLXIPL
Triglycerides
논문 1편 →TERT
Prostate cancer
논문 1편 →ADAM19
Pulmonary function
논문 1편 →PLCB1
Colorectal cancer
논문 1편 →PTPN2
Crohn's disease
논문 1편 →ADAM30
Crohn's disease
논문 1편 →FTH1
Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid)
논문 1편 →ZDHHC11
Pancreatic cancer
논문 1편 →TERT
Lung adenocarcinoma
논문 1편 →LRP1B
Body mass index
논문 1편 →KIAA0350
Type 1 diabetes
논문 1편 →IL10
Ulcerative colitis
논문 1편 →HLA-DPA1
Hepatitis B
논문 1편 →NEGR1
Obesity
논문 1편 →SLC18A1
Triglycerides
논문 1편 →TCF7L2
Psoriasis or type 2 diabetes (trans-disease meta-analysis)
논문 1편 →CYP19A1
Height
논문 1편 →G6PC2
Glycated hemoglobin levels
논문 1편 →NRTN
N-glycan levels
논문 1편 →STAT4
Systemic sclerosis
논문 1편 →NADSYN1
Vitamin D levels
논문 1편 →CSF3
White blood cell count
논문 1편 →CYP2C19
CYP2C19 *2 — clopidogrel activation
논문 1편 →MERTK
Hepatitis C induced liver fibrosis
논문 1편 →C9orf3
Atrial fibrillation
논문 1편 →ASAP1
Tuberculosis
논문 1편 →LRP1
Colorectal cancer or advanced adenoma
논문 1편 →LIPC
Triglycerides
논문 1편 →TUFM
Body fat percentage
논문 1편 →RPL27A
Body mass index
논문 1편 →RAP1A
Osteoporosis-related phenotypes
논문 1편 →SLC22A12
Urate levels
논문 1편 →SEC16B
Body mass index
논문 1편 →ABO
Soluble E-selectin levels
논문 1편 →FUT2
Pediatric autoimmune diseases
논문 1편 →SCD
Metabolic traits
논문 1편 →FURIN
Trauma exposure
논문 1편 →WIF1
Hippocampal volume
논문 1편 →UGT1A1
Bilirubin levels
논문 1편 →RREB1
Urate levels
논문 1편 →NISCH
Waist-hip ratio
논문 1편 →EDNRA
Intracranial aneurysm
논문 1편 →GLUT9
Urate levels
논문 1편 →CPEB4
Waist-hip ratio
논문 1편 →AHR
Coffee consumption
논문 1편 →DAB2IP
Abdominal aortic aneurysm
논문 1편 →MIR1307
Schizophrenia
논문 1편 →TAS2R38
Bitter taste perception (PTC/PROP tasting)
논문 1편 →SCGN
Uric acid levels
논문 1편 →CELSR2
Lipoprotein-associated phospholipase A2 activity and mass
논문 1편 →RBM43
Type 2 diabetes
논문 1편 →MLXIPL
Coffee consumption (cups per day)
논문 1편 →MSRA
Adiposity
논문 1편 →ATP11A
Glycated hemoglobin levels
논문 1편 →CFH
Circulating myeloperoxidase levels (serum)
논문 1편 →RHOU
Basal cell carcinoma
논문 1편 →JAZF1
Type 2 diabetes
논문 1편 →PROCR
Anticoagulant levels
논문 1편 →PGPEP1
Growth differentiation factor-15 levels
논문 1편 →HLA-DPB1
Hepatitis B (viral clearance)
논문 1편 →NKX2-1
Thyroid cancer
논문 1편 →URAD
Pancreatic cancer
논문 1편 →FTO
Obesity (extreme)
논문 1편 →Europe PMC에서 제목과 초록만을 대상으로 “type 2 diabetes”, “fasting glucose”, “insulin resistance”, “glycated hemoglobin” 를 공개된 각 rsID와 함께 검색했습니다. 전문 검색은 쓰지 않았습니다. 보충자료 표에 rsID가 박힌 논문까지 잡히기 때문입니다. 매달 다시 셉니다.