The one reproductive event with a date attached, and the date is partly inherited. What follows from that is smaller than the internet suggests.
Why this topic Menopause stopped being a private subject in about two years — hormone therapy is being argued about in public, employers are writing policies, and a great many products have appeared to meet the attention.
Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
Counted in Europe PMC, where the title or abstract names both this topic and that rsID. The number is papers, not evidence of a cause.
MCM8
Menopause (age at onset)
13 papers →PRRC2A
Menopause (age at onset)
5 papers →near MRPS30
Breast cancer
5 papers →BRSK1
Menarche and menopause (age at onset)
5 papers →SYCP2L
Menopause (age at onset)
4 papers →LSP1
Breast cancer
4 papers →FTO
Menarche (age at onset)
4 papers →HFE
Iron overload risk (hereditary hemochromatosis)
3 papers →MTHFR
Folate metabolism (MTHFR C677T)
3 papers →ESR1
Breast cancer
3 papers →LRP5
Bone mineral density
3 papers →SLC4A7
Breast cancer
3 papers →TLK1
Menopause (age at onset)
2 papers →TNRC6B
Uterine fibroids
2 papers →HFE
Iron overload risk (HFE H63D)
2 papers →ESR1
Bone mineral density (spine)
2 papers →COX11
Breast cancer
2 papers →CYP1A2
Caffeine metabolism
2 papers →ESR1
Bone mineral density (hip)
1 paper →INHBA
Menarche (age at onset)
1 paper →near NPIPB2
Menopause (age at onset)
1 paper →near ARL14EP
Menopause (age at onset)
1 paper →NLRP11
Menopause (age at onset)
1 paper →TOX3
Breast cancer
1 paper →ZFP36L2
Polycystic ovary syndrome
1 paper →EXO1
Menopause (age at onset)
1 paper →HLA-DQA2
Crohn's disease
1 paper →ECHDC1
Breast cancer
1 paper →GC
Vitamin D levels
1 paper →MLXIPL
Triglycerides
1 paper →SLCO1B1
Statin muscle-side-effect risk
1 paper →MCM6 / LCT
Lactose tolerance
1 paper →IL29
Chronic hepatitis C infection
1 paper →Europe PMC, title and abstract only, searched for “age at menopause”, “menopause”, “reproductive lifespan” alongside each published rsID. Full text was not counted: it returns every paper with an rsID buried in a supplementary table. Recounted monthly.