Sensitive

Breast cancer

SLC4A7 · rs4973768

Where this position leads

Condition: Breast Cancer

rs4973768 Condition: Breast Cancer Breast Cancer Condition Topic: Menopause Menopause Topic rs4973768 rs4973768 SLC4A7

Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.

What the study found

Who was studied 2,839 European ancestry cases, 3,507 European ancestry controls; replicated in 9,041 European ancestry cases, 8,980 European ancestry controls.

The effect Each copy of the C allele carried 1.14 times the odds of Breast cancer (95% confidence interval 1.09-1.19); p = 2 × 10−8.

How common The C allele had a frequency of about 49% in the people studied.

Where it sits Chromosome 3, band 3p24.1 — in the 3′ untranslated region of SLC4A7.

What each result means

C/C Two copies of the version the research linked to Breast cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Breast cancer. That is a smaller link than two copies.
T/T No copy of the version the research linked to Breast cancer. This is the starting point the study compared everyone against.
Source

What people read about alongside this

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs4973768

What is rs4973768?

rs4973768 is a single position in the genome, in or near the SLC4A7 gene. Published research associates it with breast cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs4973768 linked to?

On MyGeneLog this position is linked to Breast Cancer. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs4973768?

Subjects that appear in the title or abstract of the same papers as this rsID include menopause (3 papers), fertility (2 papers), vitamins and nutrient levels (1 papers), alcohol and the flush (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs4973768 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4973768 come from?

GWAS Catalog, J Natl Cancer Inst 2011, PMID:21263130. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Breast cancer (rs4973768). MyGeneLog™. https://www.mygenelog.com/variants/rs4973768

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