Standard

Menopause (age at onset)

MCM8 · rs16991615

Where this position leads

Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.

What the study found

Who was studied 38,968 European ancestry female individuals; replicated in Up to 14,435 European ancestry female individuals.

The effect Each copy of the A allele shifted the measure 0.948 years higher (95% confidence interval 0.85-1.05); p = 1 × 10⁻⁷³.

How common The A allele had a frequency of about 7% in the people studied.

Where it sits Chromosome 20, band 20p12.3 — a missense change in MCM8.

What each result means

A/A Two copies of the version the research linked to Menopause (age at onset). That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Menopause (age at onset). That is a smaller link than two copies.

G/G No copy of the version the research linked to Menopause (age at onset). This is the starting point the study compared everyone against.

Source

Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways

Stolk L, Perry JR, Chasman DI, He C, Mangino M, Sulem P, Barbalic M, Broer L, Byrne EM, Ernst F, Esko T, Franceschini N

and 167 more — show all

Gudbjartsson DF, Hottenga JJ, Kraft P, McArdle PF, Porcu E, Shin SY, Smith AV, van Wingerden S, Zhai G, Zhuang WV, Albrecht E, Alizadeh BZ, Aspelund T, Bandinelli S, Lauc LB, Beckmann JS, Boban M, Boerwinkle E, Broekmans FJ, Burri A, Campbell H, Chanock SJ, Chen C, Cornelis MC, Corre T, Coviello AD, d'Adamo P, Davies G, de Faire U, de Geus EJ, Deary IJ, Dedoussis GV, Deloukas P, Ebrahim S, Eiriksdottir G, Emilsson V, Eriksson JG, Fauser BC, Ferreli L, Ferrucci L, Fischer K, Folsom AR, Garcia ME, Gasparini P, Gieger C, Glazer N, Grobbee DE, Hall P, Haller T, Hankinson SE, Hass M, Hayward C, Heath AC, Hofman A, Ingelsson E, Janssens AC, Johnson AD, Karasik D, Kardia SL, Keyzer J, Kiel DP, Kolcic I, Kutalik Z, Lahti J, Lai S, Laisk T, Laven JS, Lawlor DA, Liu J, Lopez LM, Louwers YV, Magnusson PK, Marongiu M, Martin NG, Klaric IM, Masciullo C, McKnight B, Medland SE, Melzer D, Mooser V, Navarro P, Newman AB, Nyholt DR, Onland-Moret NC, Palotie A, Paré G, Parker AN, Pedersen NL, Peeters PH, Pistis G, Plump AS, Polasek O, Pop VJ, Psaty BM, Räikkönen K, Rehnberg E, Rotter JI, Rudan I, Sala C, Salumets A, Scuteri A, Singleton A, Smith JA, Snieder H, Soranzo N, Stacey SN, Starr JM, Stathopoulou MG, Stirrups K, Stolk RP, Styrkarsdottir U, Sun YV, Tenesa A, Thorand B, Toniolo D, Tryggvadottir L, Tsui K, Ulivi S, van Dam RM, van der Schouw YT, van Gils CH, van Nierop P, Vink JM, Visscher PM, Voorhuis M, Waeber G, Wallaschofski H, Wichmann HE, Widen E, Wijnands-van Gent CJ, Willemsen G, Wilson JF, Wolffenbuttel BH, Wright AF, Yerges-Armstrong LM, Zemunik T, Zgaga L, Zillikens MC, Zygmunt M, Arnold AM, Boomsma DI, Buring JE, Crisponi L, Demerath EW, Gudnason V, Harris TB, Hu FB, Hunter DJ, Launer LJ, Metspalu A, Montgomery GW, Oostra BA, Ridker PM, Sanna S, Schlessinger D, Spector TD, Stefansson K, Streeten EA, Thorsteinsdottir U, Uda M, Uitterlinden AG, van Duijn CM, Völzke H, Murray A, Murabito JM, Visser JA, Lunetta KL

LifeLines Cohort Study

Nature genetics · 2012 · PMID 22267201 · open access

What people read about alongside this

Menopause13 Longevity and ageing4 Fertility3

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs16991615

What is rs16991615?

rs16991615 is a single position in the genome, in or near the MCM8 gene. Published research associates it with menopause (age at onset). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs16991615 linked to?

On MyGeneLog this position is linked to Age at Menopause. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs16991615?

Subjects that appear in the title or abstract of the same papers as this rsID include menopause (13 papers), longevity and ageing (4 papers), fertility (3 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs16991615 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs16991615 come from?

GWAS Catalog, Nat Genet 2012, PMID:22267201. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Menopause (age at onset) (rs16991615). MyGeneLog™. https://www.mygenelog.com/variants/rs16991615

← See all variants