PRRC2A · rs1046089
Where this position leads
Condition: Age at Menopause
Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
What the study found
Who was studied 3,493 European ancestry cases, 13,598 European ancestry controls; replicated in 3,412 European ancestry cases, 4,928 European ancestry controls.
The effect Each copy of the A allele shifted the measure 0.192 years higher (95% confidence interval 0.13-0.25); p = 4 × 10−11.
How common The A allele had a frequency of about 35% in the people studied.
Where it sits Chromosome 6, band 6p21.33 — a missense change in PRRC2A.
What ClinVar records
Classification
Benign for PRRC2A-related disorder; no assertion criteria provided (0 of 4 stars, 1 submitter), last evaluated 2019-10-21.
ClinVar record 3060262 NM_004638.4(PRRC2A):c.5219G>A (p.Arg1740His)
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What people read about alongside this
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
rs1046089 is a single position in the genome, in or near the PRRC2A gene. Published research associates it with menopause (age at onset). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Age at Menopause. The research behind each link, and its sources, are set out on that condition page.
Subjects that appear in the title or abstract of the same papers as this rsID include menopause (5 papers), fertility (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Hum Mol Genet 2013, PMID:23307926. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Menopause (age at onset) (rs1046089). MyGeneLog™. https://www.mygenelog.com/variants/rs1046089