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Solid lines are connections this site curates. Dashed lines mean the two ends share a research paper — worth knowing, and not a claim that one explains the other.
What the study found
Who was studied 744 Han Chinese ancestry cases, 895 Han Chinese ancestry controls; replicated in 3,338 Han Chinese ancestry cases, 5,792 Han Chinese ancestry controls.
The effect
Each copy of the A allele carried 1.49 times the odds of Polycystic ovary syndrome (95% confidence interval 1.39-1.61); p = 2 × 10−23.
How common The A allele had a frequency of about 91% in the people studied.
Where it sits Chromosome 2, band 2p21 — in an intron of THADA.
What each result means
A/ATwo copies of the version the research linked to Polycystic ovary syndrome. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/COne copy of the version the research linked to Polycystic ovary syndrome. That is a smaller link than two copies.
C/CNo copy of the version the research linked to Polycystic ovary syndrome. This is the starting point the study compared everyone against.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs13429458
What is rs13429458?
rs13429458 is a single position in the genome, in or near the ZFP36L2 gene. Published research associates it with polycystic ovary syndrome. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs13429458 linked to?
On MyGeneLog this position is linked to Polycystic Ovary Syndrome. The research behind each link, and its sources, are set out on that condition page.
What do people read about alongside rs13429458?
Subjects that appear in the title or abstract of the same papers as this rsID include blood sugar and insulin (3 papers), fertility (3 papers), longevity and ageing (1 papers), menopause (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs13429458 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs13429458 come from?
GWAS Catalog, Nat Genet 2010, PMID:21151128. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
4 4732135121227Reads by AI crawlersClaude3ChatGPT2Google · Gemini1Perplexity3Meta AI5Microsoft · Copilot1Amazon2Apple1China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others27Total47Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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