Two entirely different questions get asked about aging genetics, and the two condition pages this topic maps to answer them separately on purpose: how long people actually live (mostly disease genetics, not an aging dial), and how old someone measures biologically right now (telomere length, DNA-methylation clocks) — with telomerase's own genes, TERT and TERC, the one real link between the two.
Why this topic Longevity moved from a supplement-marketing word to a funded research category in a few years — rapamycin and metformin are both the subject of real clinical trials asking whether an existing drug can delay aging itself, and consumer "biological age" tests built on epigenetic clocks are sold directly to the public. Checking what the underlying genetics actually says, and what it does not, is exactly this site's job.
2026-09-16 · American Federation for Aging Research (AFAR), official TAME Trial page
Checked against AFAR's own page rather than several lower-quality "2026 results" pages that did not survive checking the primary source: TAME is still in fundraising, with zero participants enrolled. See /drugs/metformin, where the two variants held here (ATM, SLC2A2) come from real diabetes pharmacogenomic studies unrelated to this aging question.
All 34 come from the source studies' own genome-wide-significant loci lists, split across two condition pages kept deliberately separate: /conditions/human-lifespan (actual survival, mostly disease genetics) and /conditions/telomere-length-and-epigenetic-aging (two lab biomarkers of aging rate). TERT and TERC, telomerase's two core components, are the one real mechanistic link stated by the source studies themselves — not a coincidence of both involving "telomere" genes.
LPA
Parental lifespan (LPA, lipoprotein(a))
ATXN2 / BRAP
Parental lifespan (ATXN2/BRAP)
TOX
Parental longevity (father's attained age)
USP2-AS1
Parental longevity (both parents in top 10%)
near MAP3K4
Parental longevity (combined parental attained age, Martingale residuals)
FPGT
Parental longevity (combined parental age at death)
near SLC22A3
Parental longevity (combined parental attained age, Martingale residuals)
CDKN2B-AS1
Parental lifespan (9p21, the coronary artery disease locus)
EBF1
Longevity (90 years and older)
CHRNA4
Parental longevity (father's attained age)
MICA
Parental longevity (father's attained age)
HLA-DQA1
Parental lifespan
near MYL2
Parental longevity (combined parental attained age, Martingale residuals)
LPA
Parental lifespan
C20orf187
Parental longevity (father's attained age)
HTT
Parental lifespan (near HTT)
ZW10
Parental longevity (father's attained age)
PROX2
Parental longevity (combined parental attained age, Martingale residuals)
FURIN / FES
Parental lifespan (FURIN/FES)
SEMA6D
Parental longevity (father's attained age)
EPHX2
Parental longevity (combined parental attained age, Martingale residuals)
CHRNA3 / CHRNA5
Parental lifespan (CHRNA3/CHRNA5 nicotine receptor cluster)
near SLC22A3
Parental longevity (combined parental attained age, Martingale residuals)
ZNF248
Extrinsic epigenetic age acceleration
TERC
Telomere length
TERC
Telomere length
KIF13A
Intrinsic epigenetic age acceleration
TERT
Intrinsic epigenetic age acceleration
CTC1
Telomere length
ZNF676
Telomere length
KIF13A
Intrinsic epigenetic age acceleration
CSNK2A2
Telomere length
TPMT
Intrinsic epigenetic age acceleration
STXBP4
Intrinsic epigenetic age acceleration
Nothing here yet. None of the variants we publish shares a paper with this topic so far. That is a statement about our catalogue, not about the research — and it is why this page has no list rather than a made-up one.
Europe PMC, title and abstract only, searched for “aging”, “ageing”, “longevity”, “biological age”, “epigenetic clock” alongside each published rsID. Full text was not counted: it returns every paper with an rsID buried in a supplementary table. Recounted monthly.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Aging and longevity. MyGeneLog™. https://www.mygenelog.com/topics/aging
Two different things get asked about under this name: how long people actually live, and how old someone measures biologically right now. This site keeps them on separate condition pages because the evidence for each is genuinely different.
Not one that this site's own data supports as a single "aging dial." The largest lifespan study found mostly disease-specific loci -- Alzheimer's risk, smoking, cholesterol -- not a general aging mechanism. FOXO3, the most commonly cited "longevity gene," has no genome-wide-significant lifespan association in the GWAS Catalog at all.
TERT and TERC, the two core components of telomerase, the enzyme that rebuilds telomeres. Each anchors one side of this topic independently, and the source study for epigenetic age acceleration states directly that telomere-length variants relate to it too.
Not co-mentions, unlike most of this site's other topic pages. Each one is from its source study's own list of genome-wide-significant loci, split across the two condition pages this topic maps to.