CHRNA4 · rs2273500
Where this position leads
Condition: Human Lifespan and Longevity
What the study found
Who was studied 415,311 British ancestry individuals.
The effect Each copy of the T allele shifted the measure 0.0176 lower (95% confidence interval 0.012-0.024); p = 2 × 10−8.
How common The T allele had a frequency of about 86% in the people studied.
Where it sits Chromosome 20, band 20q13.33 — in an intron of CHRNA4.
What ClinVar records
Classification
Benign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2024-07-15.
ClinVar record 3255299 NM_000744.7(CHRNA4):c.383+378A>G
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs2273500 is a single position in the genome, in or near the CHRNA4 gene. Published research associates it with parental longevity (father's attained age). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Human Lifespan and Longevity. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Aging (Albany NY) 2017, PMID:29227965. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Parental longevity (father's attained age) (rs2273500). MyGeneLog™. https://www.mygenelog.com/variants/rs2273500