FPGT · rs146254978
Where this position leads
Condition: Human Lifespan and Longevity
What the study found
Who was studied 208,118 British ancestry individuals.
The effect Each copy of the T allele shifted the measure 0.0692 lower (95% confidence interval 0.045-0.094); p = 5 × 10−8.
How common The T allele had a frequency of about 98% in the people studied.
Where it sits Chromosome 1, band 1p31.1 — in an intron of FPGT-TNNI3K.
rs146254978 is a single position in the genome, in or near the FPGT gene. Published research associates it with parental longevity (combined parental age at death). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Human Lifespan and Longevity. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Aging (Albany NY) 2017, PMID:29227965. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Parental longevity (combined parental age at death) (rs146254978). MyGeneLog™. https://www.mygenelog.com/variants/rs146254978