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Parental longevity (father's attained age)

MICA · rs3131621

Where this position leads

Condition: Human Lifespan and Longevity

rs3131621 Condition: Human Lifespan and Longevity Human Lifespan and Longevity Condition rs3131621 rs3131621 MICA

What the study found

Who was studied 415,311 British ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0124 lower (95% confidence interval 0.0081-0.0167); p = 4 × 10−8.

How common The A allele had a frequency of about 63% in the people studied.

Where it sits Chromosome 6, band 6p21.33 — between genes, 4.1 kb from HLA-X.

What each result means

A/A Two copies of the version the research linked to Parental longevity (father's attained age). That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Parental longevity (father's attained age). That is a smaller link than two copies.
G/G No copy of the version the research linked to Parental longevity (father's attained age). This is the starting point the study compared everyone against.
Source

Questions about rs3131621

What is rs3131621?

rs3131621 is a single position in the genome, in or near the MICA gene. Published research associates it with parental longevity (father's attained age). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs3131621 linked to?

On MyGeneLog this position is linked to Human Lifespan and Longevity. The research behind each link, and its sources, are set out on that condition page.

Does having rs3131621 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs3131621 come from?

GWAS Catalog, Aging (Albany NY) 2017, PMID:29227965. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Parental longevity (father's attained age) (rs3131621). MyGeneLog™. https://www.mygenelog.com/variants/rs3131621

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