1 3621924117Reads by AI crawlersClaude0ChatGPT0Google · Gemini2Perplexity1Meta AI9Microsoft · Copilot0Amazon2Apple4China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others17Total36Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 8,393 European ancestry individuals; replicated in 1,023 African American individuals, 491 Hispanic individuals.
The effect
Each copy of the A allele shifted the measure 0.737 higher (95% confidence interval 0.54-0.93); p = 1 × 10−13.
How common The A allele had a frequency of about 28% in the people studied.
Where it sits Chromosome 10, band 10p11.21 — between genes, 20.2 kb from ZNF25.
What each result means
A/ATwo copies of the version the research linked to Extrinsic epigenetic age acceleration. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/COne copy of the version the research linked to Extrinsic epigenetic age acceleration. That is a smaller link than two copies.
C/CNo copy of the version the research linked to Extrinsic epigenetic age acceleration. This is the starting point the study compared everyone against.
Nature communications · 2018 · PMID 29374233 · open access
Questions about rs1005277
What is rs1005277?
rs1005277 is a single position in the genome, in or near the ZNF248 gene. Published research associates it with extrinsic epigenetic age acceleration. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1005277 linked to?
On MyGeneLog this position is linked to Telomere Length and Epigenetic Age Acceleration. The research behind each link, and its sources, are set out on that condition page.
Does having rs1005277 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1005277 come from?
GWAS Catalog, Nat Commun 2018, PMID:29374233. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 3621924117Reads by AI crawlersClaude0ChatGPT0Google · Gemini2Perplexity1Meta AI9Microsoft · Copilot0Amazon2Apple4China (ByteDance, Huawei, Baidu…)1ByteDance (Doubao)1Others17Total36Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
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Extrinsic epigenetic age acceleration (rs1005277). MyGeneLog™. https://www.mygenelog.com/variants/rs1005277