C/CNeither copy carries the associated allele. A region linked to blood pressure and to coronary disease. ATXN2 is better known for a repeat expansion that causes a hereditary ataxia — a reminder that the same gene can hold a rare devastating change and a common tiny one. On its own this tells one person almost nothing: the effect is a small shift in a population average, and how long anyone lives is mostly not genetic at all.
C/TOne copy of the associated allele. Strikingly uneven: about 44% in Europe, under 2% in Africa and under 1% in East Asia. What was measured is a difference in average parental lifespan across half a million families — months, not years, and invisible in any one family.
T/TTwo copies. Still a shift in an average rather than a fact about a life. The reason to record it is what it points at biologically, not what it predicts.
This is an association with how long a population lives, not a prediction about one person. Nothing here is used clinically, nothing here is a reason to take anything, and no genotype at this position changes what anyone should do.
Source: Timmers et al., Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances, eLife 2019 (PMID 30642433); GWAS Catalog study GCST009890. Position and alleles checked against Ensembl (GRCh38). Reported P = 1e-12.
Questions about rs11065979
What is rs11065979?
rs11065979 is a single position in the genome, in or near the ATXN2 / BRAP gene. Published research associates it with parental lifespan (atxn2/brap). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs11065979 linked to?
On MyGeneLog this position is linked to Human Lifespan and Longevity. The research behind each link, and its sources, are set out on that condition page.
Does having rs11065979 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs11065979 come from?
Timmers et al., Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances, eLife 2019 (PMID 30642433); GWAS Catalog study GCST009890. Position and alleles checked against Ensembl (GRCh38). Reported P = 1e-12. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.