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Parental lifespan

HLA-DQA1 · rs34831921

Where this position leads

What the study found

Who was studied up to 586,626 European ancestry individuals, up to 19,433 African ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.6 years higher (95% confidence interval -); p = 4 × 10⁻⁸.

How common The A allele had a frequency of about 9% in the people studied.

Where it sits Chromosome 6, band 6p21.32 — between genes, 5.2 kb from HLA-DQA1.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Parental lifespan compared to the general population.

A/C Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Parental lifespan.

C/C Published research associates this genotype with typical/baseline likelihood of Parental lifespan — no copies of the reported risk allele.

Source

Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity

Joshi PK, Pirastu N, Kentistou KA, Fischer K, Hofer E, Schraut KE, Clark DW, Nutile T, Barnes CLK, Timmers PRHJ, Shen X, Gandin I

and 101 more — show all

McDaid AF, Hansen TF, Gordon SD, Giulianini F, Boutin TS, Abdellaoui A, Zhao W, Medina-Gomez C, Bartz TM, Trompet S, Lange LA, Raffield L, van der Spek A, Galesloot TE, Proitsi P, Yanek LR, Bielak LF, Payton A, Murgia F, Concas MP, Biino G, Tajuddin SM, Seppälä I, Amin N, Boerwinkle E, Børglum AD, Campbell A, Demerath EW, Demuth I, Faul JD, Ford I, Gialluisi A, Gögele M, Graff M, Hingorani A, Hottenga JJ, Hougaard DM, Hurme MA, Ikram MA, Jylhä M, Kuh D, Ligthart L, Lill CM, Lindenberger U, Lumley T, Mägi R, Marques-Vidal P, Medland SE, Milani L, Nagy R, Ollier WER, Peyser PA, Pramstaller PP, Ridker PM, Rivadeneira F, Ruggiero D, Saba Y, Schmidt R, Schmidt H, Slagboom PE, Smith BH, Smith JA, Sotoodehnia N, Steinhagen-Thiessen E, van Rooij FJA, Verbeek AL, Vermeulen SH, Vollenweider P, Wang Y, Werge T, Whitfield JB, Zonderman AB, Lehtimäki T, Evans MK, Pirastu M, Fuchsberger C, Bertram L, Pendleton N, Kardia SLR, Ciullo M, Becker DM, Wong A, Psaty BM, van Duijn CM, Wilson JG, Jukema JW, Kiemeney L, Uitterlinden AG, Franceschini N, North KE, Weir DR, Metspalu A, Boomsma DI, Hayward C, Chasman D, Martin NG, Sattar N, Campbell H, Esko T, Kutalik Z, Wilson JF

Nature communications · 2017 · PMID 29030599 · open access

Questions about rs34831921

What is rs34831921?

rs34831921 is a single position in the genome, in or near the HLA-DQA1 gene. Published research associates it with parental lifespan. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs34831921 linked to?

On MyGeneLog this position is linked to Human Lifespan and Longevity. The research behind each link, and its sources, are set out on that condition page.

Does having rs34831921 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs34831921 come from?

GWAS Catalog, Nat Commun 2017, PMID:29030599. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

← See all variants