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Parental lifespan (9p21, the coronary artery disease locus)

CDKN2B-AS1 · rs1556516

Where this position leads

Condition: Human Lifespan and Longevity

rs1556516 Condition: Human Lifespan and Longevity Human Lifespan and Longevity Condition rs1556516 rs1556516 CDKN2B-AS1

What each result means

A/A Neither copy carries the associated allele. This is 9p21 — the first and most reproducible coronary artery disease locus ever found, in a long non-coding RNA rather than a protein-coding gene. Its appearance here is the page in miniature: a heart-disease position turning up as a lifespan position. On its own this tells one person almost nothing: the effect is a small shift in a population average, and how long anyone lives is mostly not genetic at all.
A/G One copy of the associated allele. About 50% in Europe, 30% in East Asia, and only 3% in Africa. What was measured is a difference in average parental lifespan across half a million families — months, not years, and invisible in any one family.
G/G Two copies. Still a shift in an average rather than a fact about a life. The reason to record it is what it points at biologically, not what it predicts.
This is an association with how long a population lives, not a prediction about one person. Nothing here is used clinically, nothing here is a reason to take anything, and no genotype at this position changes what anyone should do.

Source: Timmers et al., Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances, eLife 2019 (PMID 30642433); GWAS Catalog study GCST009890. Position and alleles checked against Ensembl (GRCh38). Reported P = 7e-11.

What people read about alongside this

Longevity and ageing1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs1556516

What is rs1556516?

rs1556516 is a single position in the genome, in or near the CDKN2B-AS1 gene. Published research associates it with parental lifespan (9p21, the coronary artery disease locus). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1556516 linked to?

On MyGeneLog this position is linked to Human Lifespan and Longevity. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs1556516?

Subjects that appear in the title or abstract of the same papers as this rsID include longevity and ageing (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs1556516 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1556516 come from?

Timmers et al., Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances, eLife 2019 (PMID 30642433); GWAS Catalog study GCST009890. Position and alleles checked against Ensembl (GRCh38). Reported P = 7e-11. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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