Parental lifespan (9p21, the coronary artery disease locus)
CDKN2B-AS1 · rs1556516
1 4823117123226Reads by AI crawlersClaude2ChatGPT3Google · Gemini1Perplexity1Meta AI7Microsoft · Copilot1Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others26Total48Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
A/ANeither copy carries the associated allele. This is 9p21 — the first and most reproducible coronary artery disease locus ever found, in a long non-coding RNA rather than a protein-coding gene. Its appearance here is the page in miniature: a heart-disease position turning up as a lifespan position. On its own this tells one person almost nothing: the effect is a small shift in a population average, and how long anyone lives is mostly not genetic at all.
A/GOne copy of the associated allele. About 50% in Europe, 30% in East Asia, and only 3% in Africa. What was measured is a difference in average parental lifespan across half a million families — months, not years, and invisible in any one family.
G/GTwo copies. Still a shift in an average rather than a fact about a life. The reason to record it is what it points at biologically, not what it predicts.
This is an association with how long a population lives, not a prediction about one person. Nothing here is used clinically, nothing here is a reason to take anything, and no genotype at this position changes what anyone should do.
Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.
Questions about rs1556516
What is rs1556516?
rs1556516 is a single position in the genome, in or near the CDKN2B-AS1 gene. Published research associates it with parental lifespan (9p21, the coronary artery disease locus). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs1556516 linked to?
On MyGeneLog this position is linked to Human Lifespan and Longevity. The research behind each link, and its sources, are set out on that condition page.
What do people read about alongside rs1556516?
Subjects that appear in the title or abstract of the same papers as this rsID include longevity and ageing (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.
Does having rs1556516 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs1556516 come from?
Timmers et al., Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances, eLife 2019 (PMID 30642433); GWAS Catalog study GCST009890. Position and alleles checked against Ensembl (GRCh38). Reported P = 7e-11. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 4823117123226Reads by AI crawlersClaude2ChatGPT3Google · Gemini1Perplexity1Meta AI7Microsoft · Copilot1Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others26Total48Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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