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Intrinsic epigenetic age acceleration

STXBP4 · rs78781855

Where this position leads

Condition: Telomere Length and Epigenetic Age Acceleration

rs78781855 Condition: Telomere Length and Epigenetic Age Acceleration Telomere Length and Epigenetic Age … Condition rs78781855 rs78781855 STXBP4

What the study found

Who was studied 8,393 European ancestry individuals; replicated in 1,023 African American individuals, 491 Hispanic individuals.

The effect Each copy of the G allele shifted the measure 0.475 lower (95% confidence interval 0.32-0.63); p = 6 × 10−9.

How common The G allele had a frequency of about 22% in the people studied.

Where it sits Chromosome 17, band 17q22 — in an intron of STXBP4.

What each result means

G/G Two copies of the version the research linked to Intrinsic epigenetic age acceleration. That is the strongest link of the three results. A link in a study is not a diagnosis.
G/T One copy of the version the research linked to Intrinsic epigenetic age acceleration. That is a smaller link than two copies.
T/T No copy of the version the research linked to Intrinsic epigenetic age acceleration. This is the starting point the study compared everyone against.
Source

Questions about rs78781855

What is rs78781855?

rs78781855 is a single position in the genome, in or near the STXBP4 gene. Published research associates it with intrinsic epigenetic age acceleration. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs78781855 linked to?

On MyGeneLog this position is linked to Telomere Length and Epigenetic Age Acceleration. The research behind each link, and its sources, are set out on that condition page.

Does having rs78781855 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs78781855 come from?

GWAS Catalog, Nat Commun 2018, PMID:29374233. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Intrinsic epigenetic age acceleration (rs78781855). MyGeneLog™. https://www.mygenelog.com/variants/rs78781855

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