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Parental lifespan (CHRNA3/CHRNA5 nicotine receptor cluster)

CHRNA3 / CHRNA5 · rs8042849

Where this position leads

Condition: Human Lifespan and Longevity

rs8042849 Condition: Human Lifespan and Longevity Human Lifespan and Longevity Condition rs8042849 rs8042849 CHRNA3 / CHR…

What each result means

C/C Two copies. Still a shift in an average rather than a fact about a life. The reason to record it is what it points at biologically, not what it predicts.
T/C One copy of the associated allele. Common everywhere: about 39% in Europe, 40% in Africa, 16% in East Asia. What was measured is a difference in average parental lifespan across half a million families — months, not years, and invisible in any one family.
T/T Neither copy carries the associated allele. This position sits in the nicotinic acetylcholine receptor cluster — the same locus that turns up in every study of how much people smoke. It is the second-strongest lifespan signal in a million families, and it is a smoking variant, not an ageing one. On its own this tells one person almost nothing: the effect is a small shift in a population average, and how long anyone lives is mostly not genetic at all.
This is an association with how long a population lives, not a prediction about one person. Nothing here is used clinically, nothing here is a reason to take anything, and no genotype at this position changes what anyone should do.

Source: Timmers et al., Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances, eLife 2019 (PMID 30642433); GWAS Catalog study GCST009890. Position and alleles checked against Ensembl (GRCh38). Reported P = 2e-26.

What people read about alongside this

Alcohol and the flush1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs8042849

What is rs8042849?

rs8042849 is a single position in the genome, in or near the CHRNA3 / CHRNA5 gene. Published research associates it with parental lifespan (chrna3/chrna5 nicotine receptor cluster). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs8042849 linked to?

On MyGeneLog this position is linked to Human Lifespan and Longevity. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs8042849?

Subjects that appear in the title or abstract of the same papers as this rsID include alcohol and the flush (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs8042849 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs8042849 come from?

Timmers et al., Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances, eLife 2019 (PMID 30642433); GWAS Catalog study GCST009890. Position and alleles checked against Ensembl (GRCh38). Reported P = 2e-26. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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