Each page covers one condition properly: what it actually is and what it feels like, what causes it, how common it really is and in whom, and how it's diagnosed — followed by the specific variants with a replicated link to it, and, where the research supports it, how genetics can change the way a medicine behaves.
Written in two registers so one page serves both readers: plain language first, then a clinical detail section with the precise terminology, effect sizes and diagnostic thresholds. Every claim is sourced from freely-available published research and cited on the page, so you can check us — or hand the page to your doctor. 385 conditions so far, growing continuously, and free to reuse with attribution (CC BY 4.0).
37 results in Cancer
Cancer of Other Male Genital Organs, as genome-wide studies have reported it: 4 positions from 1 study, the largest recording 3,018 cases and 569,607 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). Assembled by code from the GWAS Catalog's records and kept current as positions arrive; every figure is the studies' own.
Read more → CancerCancer of Major Salivary Glands, as genome-wide studies have reported it: 5 positions from 1 study, the largest recording 1,130 cases and 571,603 controls (African American or Afro-Caribbean ancestry, European ancestry). Built from the GWAS Catalog's records and rebuilt when a new position is reported; the figures are the studies'.
Read more → CancerNeuroendocrine Tumors, as genome-wide studies have reported it: 14 positions from 1 study, the largest recording 751 cases and 572,091 controls (African American or Afro-Caribbean ancestry, European ancestry). Built from the GWAS Catalog's records and rebuilt when a new position is reported; the figures are the studies'.
Read more → CancerKeratinocyte Cancer, as genome-wide studies have reported it: 4 positions from 1 study, the largest recording 18,538 cases and 340,302 controls (European ancestry). Assembled by code from the GWAS Catalog's records and kept current as positions arrive; every figure is the studies' own.
Read more → CancerSquamous Cell Carcinoma, as genome-wide studies have reported it: 7 positions from 3 studies, the largest recording 9,674 cases and 625,657 controls (European ancestry). Assembled by code from the GWAS Catalog's records and kept current as positions arrive; every figure is the studies' own.
Read more → CancerCutaneous Squamous Cell Carcinoma, as genome-wide studies have reported it: 4 positions from 2 studies, the largest recording 16,407 cases and 762,486 controls (European ancestry). Built from the GWAS Catalog's records and rebuilt when a new position is reported; the figures are the studies'.
Read more → CancerNeuroblastoma, as genome-wide studies have reported it: 3 positions from 2 studies, the largest recording 2,101 cases and 4,202 controls (European ancestry). Every figure comes from the studies themselves, gathered by code from the GWAS Catalog and updated as the records grow.
Read more → CancerThe deadliest common skin cancer, and the one most tied to sun exposure acting on a genetically susceptible person. A meta-analysis of almost 16,000 melanoma cases confirmed 13 known risk loci and found five new ones, in genes tied to how melanocytes are regulated.
Read more → CancerThree separate large studies, each adding loci to a genetic picture that converges on one specific mechanism: dysfunction in the germinal center where B cells normally mature, plus disrupted T-cell development.
Read more → CancerA pediatric bone cancer defined by an acquired gene fusion — and one of this page's three inherited risk variants sits directly beside a gene that same fusion protein switches on.
Read more → CancerThe most common and clinically aggressive lymphoma subtype, whose inherited risk loci point at immune recognition pathways — including two independent signals at the same 8q24.21 region as the MYC oncogene, famous for a completely different, acquired role in this disease.
Read more → CancerA blood cancer whose strongest inherited risk sits in the immune system's own HLA region — and whose most characteristic acquired feature, a translocation at BCL2, shares a gene with one of this page's five inherited variants.
Read more → CancerBlood cancers driven by an acquired mutation in blood stem cells, most often in JAK2 — the same gene where several of this page's eight inherited variants also sit, but as a completely different, inherited kind of change.
Read more → CancerA cancer of plasma cells, the antibody-producing white blood cells. Three studies that built directly on each other tripled the number of confirmed risk loci in five years, converging on the same developmental process that makes a normal plasma cell in the first place.
Read more → CancerThe most common kind of kidney cancer in adults. Six risk loci were already known before this study; a large European-ancestry meta-analysis found seven more, five of which are the variants on this page.
Read more → CancerThe most common subtype of classical Hodgkin lymphoma in Western countries, with genetics of its own beyond the one locus shared by the disease as a whole. The variant here sits near GATA3, a transcription factor central to how immune cells develop — the same immune process the study's other nodular-sclerosis-specific loci cluster around.
Read more → CancerA distinct histological subtype of ovarian cancer, separate from the more common serous subtype already covered on this site's Ovarian Cancer page. The variant here sits near a gene pair — IFNL3/IFNL4 — almost entirely known for a different disease: predicting how the immune system responds to hepatitis C.
Read more → CancerOvarian cancer is not one disease — clear cell carcinoma is a distinct, less common histotype, more resistant to standard chemotherapy and more strongly linked to endometriosis. HNF1B, the gene this page's variant sits in, is the most consistently replicated clear-cell-specific susceptibility locus in the literature.
Read more → CancerStomach cancer is split by location — cardia versus non-cardia — because the two behave differently and are linked to different causes, Helicobacter pylori chief among them for the non-cardia form covered here. A pooled Chinese study found a new locus at 1q22 specific to East Asian populations, near ASH1L.
Read more → Cancer"Squamous cell carcinoma" without a qualifier most often means skin cancer — this page is about the lung. A three-stage Han Chinese study found one variant that lowers risk specifically for this histotype; a much larger 2017 meta-analysis then added five more, four of which cluster in one region on chromosome 6.
Read more →Showing 20 of 37 · page 1 of 2
One diagnosed condition or measurable trait covered properly: what it actually is, what causes it, how common it is, how it is diagnosed, and the specific variants with a replicated link to it — every claim sourced from published research.
No. Every page here is informational, not a diagnosis. A result should be discussed with a doctor or a licensed genetic counselor, never acted on alone.
Because they are not disorders. Height, ABO blood group and a handful of others describe a measurable characteristic with nothing to diagnose — "Trait" says so plainly instead of implying a disease that is not one.
Only after a replicated association in published research, verified against the primary study rather than a gene name or a marketing claim — the same discipline the variant pages themselves follow.