Each page covers one condition properly: what it actually is and what it feels like, what causes it, how common it really is and in whom, and how it's diagnosed — followed by the specific variants with a replicated link to it, and, where the research supports it, how genetics can change the way a medicine behaves.
Written in two registers so one page serves both readers: plain language first, then a clinical detail section with the precise terminology, effect sizes and diagnostic thresholds. Every claim is sourced from freely-available published research and cited on the page, so you can check us — or hand the page to your doctor. 385 conditions so far, growing continuously, and free to reuse with attribution (CC BY 4.0).
7 results in Immunologic
A kidney disorder causing heavy protein loss in urine, usually responsive to steroid treatment in children — a 2018 transethnic GWAS across European, African and Maghrebian ancestries found a strong HLA-DRB1 risk association.
Read more → ImmunologicThe most common primary immunodeficiency, usually mild or symptom-free — a 2016 GWAS named four risk loci directly in its title, one of them the ATG13/AMBRA1 region represented on this page.
Read more → ImmunologicAn inflammatory disease of unknown cause that forms tiny clusters of immune cells in organs, most often the lungs — a 2016 fine-mapping study found its genetics concentrate overwhelmingly in the MHC region, and differ measurably between its two main clinical presentations.
Read more → ImmunologicFor a few years this was the pharmacogenomic test people actually ordered: it predicted who would respond to interferon. Then the drugs changed, and a marker that once decided treatment became a historical curiosity. That is the most useful thing this page has to say.
Read more → ImmunologicA lifelong inflammatory bowel disease that can affect any part of the digestive tract. Its genetics are unusually well mapped — NOD2 was the first susceptibility gene ever found for a common complex disease, and IL23R showed a drug class where to aim.
Read more → ImmunologicA common FUT2 variant determines whether ABO blood-group antigens appear in saliva, gut mucus and other secretions; the roughly one in five people who are "non-secretors" are strongly resistant to the dominant norovirus strains.
Read more → ImmunologicA 32-base-pair deletion in the CCR5 gene that removes a key HIV-1 entry receptor from immune cells; two copies confer strong resistance to CCR5-tropic HIV-1, while one copy slows disease progression without preventing infection.
Read more →One diagnosed condition or measurable trait covered properly: what it actually is, what causes it, how common it is, how it is diagnosed, and the specific variants with a replicated link to it — every claim sourced from published research.
No. Every page here is informational, not a diagnosis. A result should be discussed with a doctor or a licensed genetic counselor, never acted on alone.
Because they are not disorders. Height, ABO blood group and a handful of others describe a measurable characteristic with nothing to diagnose — "Trait" says so plainly instead of implying a disease that is not one.
Only after a replicated association in published research, verified against the primary study rather than a gene name or a marketing claim — the same discipline the variant pages themselves follow.