Each page covers one condition properly: what it actually is and what it feels like, what causes it, how common it really is and in whom, and how it's diagnosed — followed by the specific variants with a replicated link to it, and, where the research supports it, how genetics can change the way a medicine behaves.
Written in two registers so one page serves both readers: plain language first, then a clinical detail section with the precise terminology, effect sizes and diagnostic thresholds. Every claim is sourced from freely-available published research and cited on the page, so you can check us — or hand the page to your doctor. 385 conditions so far, growing continuously, and free to reuse with attribution (CC BY 4.0).
15 results in Metabolic
Diabetes (standard GWA), as genome-wide studies have reported it: 4 positions from 1 study, the largest recording 283,227 individuals (European ancestry). Every figure comes from the studies themselves, gathered by code from the GWAS Catalog and updated as the records grow.
Read more → MetabolicFamilial Combined Hyperlipidemia Defined by Consensus Criteria, as genome-wide studies have reported it: 4 positions from 1 study, the largest recording 39,961 cases and 309,261 controls. Assembled by code from the GWAS Catalog's records and kept current as positions arrive; every figure is the studies' own.
Read more → MetabolicAbnormally low "good" cholesterol, studied across sex and life stage in over 50,000 Korean adults — the study’s real finding was that menopause, not age, is what turns up the genetic risk.
Read more → MetabolicFat builds up in the liver without heavy alcohol use behind it. A Korean study deliberately excluded everyone with obesity, diabetes, high cholesterol or metabolic syndrome from its search — because those conditions are themselves heritable, and a normal study risks finding their genetics instead of the liver disease's own. One variant survived that stricter test.
Read more → MetabolicNot how much fat a person carries, but where. One landmark study found that reaching the same waist-to-hip ratio through too little hip fat carries more diabetes and heart-disease risk than reaching it through too much waist fat. A second, larger study of the same trait found the genetic effects themselves often differ between women and men.
Read more → MetabolicMost heavy drinkers never develop cirrhosis, which is what made this disease worth a genetic search. The paper behind this page confirmed the field's leading known gene and found two more — and all three turn out to be lipid genes, not alcohol-metabolism genes.
Read more → MetabolicFive measurements — abdominal obesity, high triglycerides, low HDL, high blood pressure and high glucose — that cluster in the same people. Three independent studies, in three different populations, all asked whether that clustering shares a genetic cause and all three answered no, or close to it.
Read more → MetabolicTwo numbers describe most of what a kidney is doing: how fast it filters, and how much albumin leaks into urine. Both are heritable. One of the genes here raises the albumin number without harming the kidney at all, and the albumin number and blood pressure turn out to drive each other in both directions.
Read more → MetabolicTwo genes do most of the inherited work here, and both of them are plumbing: one moves urate out through the kidney, the other out through the gut. Neither is a reason to test, and one of them is a reason to be careful with a drug.
Read more → MetabolicOne in nine adults worldwide lives with diabetes, and the great majority of it is type 2. Hundreds of variants each nudge the risk a little — and what you eat, which your genes also have a say in, does more.
Read more → MetabolicA common variant near the FTO gene is linked to a small average increase in body weight and BMI by nudging appetite regulation. Most carriers never become obese — environment and behavior still matter most.
Read more → MetabolicA common East Asian genetic variant that leaves the body unable to fully break down a toxic alcohol byproduct, causing facial flushing and, with regular drinking, a substantially elevated risk of esophageal cancer.
Read more → MetabolicWhether you can comfortably drink milk as an adult comes down largely to a single DNA switch near the LCT gene. Persistent lactase activity is the evolutionary exception in humans, not the default.
Read more → MetabolicTwo very common MTHFR variants modestly change how efficiently one folate-processing enzyme works. They are heavily over-claimed online; here is what the published evidence actually supports, and what it does not.
Read more → MetabolicAn inherited condition in which the body absorbs more iron from food than it needs. Over decades the surplus iron can build up in the liver, heart, pancreas and joints and cause damage.
Read more →One diagnosed condition or measurable trait covered properly: what it actually is, what causes it, how common it is, how it is diagnosed, and the specific variants with a replicated link to it — every claim sourced from published research.
No. Every page here is informational, not a diagnosis. A result should be discussed with a doctor or a licensed genetic counselor, never acted on alone.
Because they are not disorders. Height, ABO blood group and a handful of others describe a measurable characteristic with nothing to diagnose — "Trait" says so plainly instead of implying a disease that is not one.
Only after a replicated association in published research, verified against the primary study rather than a gene name or a marketing claim — the same discipline the variant pages themselves follow.