Each page covers one condition properly: what it actually is and what it feels like, what causes it, how common it really is and in whom, and how it's diagnosed — followed by the specific variants with a replicated link to it, and, where the research supports it, how genetics can change the way a medicine behaves.
Written in two registers so one page serves both readers: plain language first, then a clinical detail section with the precise terminology, effect sizes and diagnostic thresholds. Every claim is sourced from freely-available published research and cited on the page, so you can check us — or hand the page to your doctor. 385 conditions so far, growing continuously, and free to reuse with attribution (CC BY 4.0).
6 results in Endocrine
Autoimmune Addison's disease is the immune system's destruction of the adrenal cortex. The first genome-wide study of it found nine risk loci: immune genes it shares with other autoimmune diseases, and AIRE, a gene that teaches the immune system what not to attack.
Read more → EndocrineAn enlarged thyroid with one or more lumps, almost always non-cancerous -- and, per the largest thyroid genetics study yet, genetically correlated with the disease it is most often confused with the risk of: thyroid cancer.
Read more → EndocrineExcessive hair growth in women is usually attributed to one cause — but a genome-wide study designed specifically to look beyond it found a rare, unusually strong-effect variant that most studies its size would have missed.
Read more → EndocrineAn underactive thyroid, whose genetic risk spans two different kinds of biology at once — autoimmune loci shared with many other immune diseases, and genes directly involved in making and regulating thyroid hormone.
Read more → EndocrineThe most common benign tumor of the female reproductive tract, and the leading reason for hysterectomy — genetics shows it shares real biological ground with a second, very different-looking condition: endometriosis.
Read more → EndocrineA condition defined by a committee, with no single test — and the genetics still found something. The strongest locus reached an odds ratio of 0.67, which for a common variant is large.
Read more →One diagnosed condition or measurable trait covered properly: what it actually is, what causes it, how common it is, how it is diagnosed, and the specific variants with a replicated link to it — every claim sourced from published research.
No. Every page here is informational, not a diagnosis. A result should be discussed with a doctor or a licensed genetic counselor, never acted on alone.
Because they are not disorders. Height, ABO blood group and a handful of others describe a measurable characteristic with nothing to diagnose — "Trait" says so plainly instead of implying a disease that is not one.
Only after a replicated association in published research, verified against the primary study rather than a gene name or a marketing claim — the same discipline the variant pages themselves follow.