Keratinocyte Cancer, as genome-wide studies have reported it: 3 positions from 1 study, the largest recording 18,538 cases and 340,302 controls (European ancestry). Assembled by code from the GWAS Catalog's records and kept current as positions arrive; every figure is the studies' own.
Keratinocyte Cancer — filed in the GWAS Catalog as "Keratinocyte cancer (MTAG)" — is a condition this catalogue follows as its positions arrive. This page is assembled by MyGeneLog's own code from the catalogue's records and the studies' own listings: 3 positions from 1 study, and no sentence written by hand. It is rebuilt as new positions are reported, so what it says is what the records say today.
Liyanage UE et al. 2019, in Human Molecular Genetics — Combined analysis of keratinocyte cancers identifies novel genome-wide loci. Sample in the catalogue's record: 18,538 cases and 340,302 controls (European ancestry). It contributes 3 positions: rs638907 (KRT5), rs2776348 (LINC00111), rs144984465 (GOLPH3L). PMID:31174203.
The 3 positions lie in or near 3 genes: KRT5, LINC00111, GOLPH3L. A gene named here is the catalogue's mapped location for a position, not a mechanism; the studies are cited above so that a reader can go to them.
The strongest association in the records is rs638907 in KRT5, reported by Liyanage UE et al. 2019 at P = 2 × 10-23, with an odds ratio of 1.11.
Association records say which positions differ, on average, between people with Keratinocyte Cancer and people without. They do not describe the condition, say how common it is, or tell anyone what to do, so this page does not either. For a single position, open its variant page: it gives that study's record in fixed sentences, with ClinVar's where there is one.
Nothing on this page diagnoses Keratinocyte Cancer. The 3 variants here are research findings; no guideline uses them to predict, screen for or diagnose the condition — that is a clinician's work.
This page was assembled by code from association records. It holds no clinical guidance, because its sources hold none: a genome-wide study reports which positions differ between people with a condition and people without, at the population level, and that is all this page repeats. A question about a symptom, a test or a treatment belongs with a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Keratinocyte Cancer comes down to these specific, well-studied positions — not a diagnosis.
The studies behind these variants recruited participants from different ancestries — a result found in one population doesn't always transfer to another. Based on 3 of 3 linked studies with a resolved discovery ancestry.
Databases, guidelines and references
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Keratinocyte Cancer. MyGeneLog™. https://www.mygenelog.com/conditions/keratinocyte-cancer
Keratinocyte Cancer is the condition the GWAS Catalog files under "Keratinocyte cancer (MTAG)". This page does not define it in its own words; it lists what genome-wide studies have reported: 3 positions from 1 study, with each study's sample and citation.
Genes play a part: 3 positions have been linked to it, the largest study recording 18,538 cases and 340,302 controls (European ancestry). But each is a common variant of small effect, and a link found across a population does not cause the condition in any one person.
The catalogue maps the positions to 3 genes: KRT5, LINC00111, GOLPH3L. These are where the positions sit, not proof of how they act.
No. Each variant shifts the odds only slightly, and only on average across many people. No guideline predicts Keratinocyte Cancer from a genotype; a clinician diagnoses it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.